Xu Yaqian, Wang Thanh, Yin Jia, Hu Ligang, Liao Chunyang
School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Eco Environ Health. 2024 Mar 28;3(3):266-270. doi: 10.1016/j.eehl.2024.03.003. eCollection 2024 Sep.
Currently, many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female reproduction. Since 2017, China's birth rate has hit historic lows and continued to decline, with the death rate now equaling the birth rate. Concerns have emerged regarding the potential impact of environmental contaminants on reproductive health, including pregnancy loss. Endocrine-disrupting chemicals (EDCs) like phthalate esters (PAEs), bisphenol A (BPA), triclosan (TCS), and perfluoroalkyl substances (PFASs) have raised attention due to their adverse effects on biological systems. While China's 14th Five-Year Plan (2021-2025) for national economic and social development included the treatment of emerging pollutants, including EDCs, there are currently no national appraisal standards or regulatory frameworks for EDCs and their mixtures. Addressing the risk of EDC mixtures is an urgent matter that needs consideration from China's perspective in the near future. In this Perspective, we delve into the link between EDC mixture exposure and pregnancy loss in China. Our focus areas include establishing a comprehensive national plan targeting reproductive-aged women across diverse urban and rural areas, understanding common EDC combinations in women and their surrounding environment, exploring the relationship between EDCs and pregnancy loss via epidemiology, and reconsidering the safety of EDCs, particularly in mixtures and low-dose scenarios. We envision that this study could aid in creating preventive strategies and interventions to alleviate potential risks induced by EDC exposure during pregnancy in China.
目前，由于女性生育率持续低迷，全球许多国家和地区都面临着人口增长下降的挑战。自2017年以来，中国的出生率创下历史新低且持续下降，目前死亡率与出生率持平。人们开始关注环境污染物对生殖健康的潜在影响，包括流产。邻苯二甲酸酯（PAEs）、双酚A（BPA）、三氯生（TCS）和全氟烷基物质（PFASs）等内分泌干扰化学物质（EDCs）因其对生物系统的不利影响而受到关注。虽然中国国民经济和社会发展第十四个五年规划（2021 - 2025年）包括对包括EDCs在内的新兴污染物的治理，但目前尚无针对EDCs及其混合物的国家评估标准或监管框架。应对EDC混合物的风险是一件紧迫的事情，需要在不久的将来从中国的角度加以考虑。在这篇观点文章中，我们深入探讨了中国EDC混合物暴露与流产之间的联系。我们的重点领域包括制定一项针对城乡不同地区育龄妇女的全面国家计划，了解女性及其周围环境中常见的EDC组合，通过流行病学探索EDCs与流产之间的关系，以及重新审视EDCs的安全性，特别是在混合物和低剂量情况下。我们设想这项研究有助于制定预防策略和干预措施，以减轻中国孕期EDC暴露所引发的潜在风险。
