Dmuhovskis Anzejs, Taube Maris
Faculty of Residency, Riga Stradiņš University, Riga, Latvia.
Department for Depression and Crisis, Riga Center of Psychiatry and Narcology, Riga, Latvia.
Front Psychiatry. 2024 Aug 21;15:1452980. doi: 10.3389/fpsyt.2024.1452980. eCollection 2024.
The task of a psychiatrist is to select the most appropriate medication or combination of drugs to treat the symptoms of schizophrenia while minimizing the risk of side effects and ensuring the patient achieves the highest level of functioning possible. This is a challenging task as the action of each drug or group of drugs is different. The efficacy of cariprazine, which affects D3 receptors as a D3/D2 receptor partial agonist, has been extensively studied and is one of the first medication choices by practicing psychiatrists when treating patients with negative symptomatology. In this clinical case, we demonstrate the effective and safe treatment of a patient's positive and affective symptoms using a combination of cariprazine, clozapine, and venlafaxine.
精神科医生的任务是选择最合适的药物或药物组合来治疗精神分裂症的症状,同时将副作用风险降至最低,并确保患者达到尽可能高的功能水平。这是一项具有挑战性的任务,因为每种药物或药物组的作用都不同。卡立哌嗪作为D3/D2受体部分激动剂作用于D3受体,其疗效已得到广泛研究,是执业精神科医生治疗有阴性症状的患者时的首选药物之一。在本临床病例中,我们展示了使用卡立哌嗪、氯氮平和文拉法辛联合治疗患者的阳性和情感症状的有效性和安全性。