Hebebrand Johannes, Antel Jochen, Conceição Eva, Matthews Abigail, Hinney Anke, Peters Triinu
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Essen (AöR), University of Duisburg-Essen, Essen, Germany.
Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Int J Eat Disord. 2024 Dec;57(12):2461-2468. doi: 10.1002/eat.24286. Epub 2024 Sep 5.
Post-operative development of restrictive eating disorders can occur in patients after bariatric surgery. In children and adolescents with anorexia nervosa (AN) or atypical AN, premorbid body mass index (BMI) has recently been shown to predict total weight loss. We hypothesized that pre-operative BMI similarly predicts weight loss and the development of a restrictive eating disorder in adult bariatric patients.
A PubMed search identified case studies/series of 29 adult females who developed AN or atypical AN/eating disorder not otherwise specified following bariatric surgery. Non-parametric Spearman's correlation (r ) between pre-operative BMI and total weight loss was calculated; a scatterplot was used to illustrate the relationship between pre-operative/premorbid BMI and weight loss in kg for 29 bariatric patients and 460 children and adolescents with AN or atypical AN as published previously.
The correlation between pre-operative BMI and weight loss among bariatric patients was r = 0.65 (p = 0.0001). Scatterplot data of this relationship fit the previously identified pattern in children and adolescents with AN or atypical AN.
The prediction of weight loss by pre-operative/premorbid BMI appears applicable across the weight spectrum, from underweight to severe obesity, thus strengthening our hypothesis of underlying regulatory mechanisms for the development of AN and atypical AN. Such data may guide the determination of critical weight loss thresholds that trigger eating disorder development in predisposed individuals.
减肥手术后患者可能会出现限制性饮食障碍。最近有研究表明，在患有神经性厌食症（AN）或非典型AN的儿童和青少年中，病前体重指数（BMI）可预测总体体重减轻。我们假设，术前BMI同样可预测成年减肥患者的体重减轻及限制性饮食障碍的发生。
通过PubMed检索，确定了29例成年女性减肥手术后发生AN或非典型AN/未另行说明的饮食障碍的病例研究/系列。计算术前BMI与总体体重减轻之间的非参数Spearman相关性（r）；使用散点图说明29例减肥患者以及之前发表的460例患有AN或非典型AN的儿童和青少年术前/病前BMI与体重减轻（以千克为单位）之间的关系。
减肥患者术前BMI与体重减轻之间的相关性为r = 0.65（p = 0.0001）。这种关系的散点图数据符合之前在患有AN或非典型AN的儿童和青少年中确定的模式。
术前/病前BMI对体重减轻的预测似乎适用于从体重过轻到严重肥胖的整个体重范围，从而强化了我们关于AN和非典型AN发生的潜在调节机制的假设。这些数据可能有助于确定触发易感个体饮食障碍发生的临界体重减轻阈值。
