评估 N 末端脑利钠肽前体在急性磷化铝中毒患者死亡率预测中的作用。
Assessment of the role of N-terminal pro-B-type natriuretic peptide as a predictive biomarker of mortality in acute aluminum phosphide poisoning.
机构信息
Department of Forensic Medicine and Clinical toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
Biomarkers. 2024 Sep;29(6):376-383. doi: 10.1080/1354750X.2024.2400910. Epub 2024 Sep 13.
BACKGROUND
In Egypt, aluminum phosphide (ALP) is a known lethal poison due to its cardiotoxicity. This study aimed to evaluate the predictive ability of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for mortality in ALP-poisoned patients.
METHODS
This prospective study was conducted on patients with ALP poisoning admitted to the Poison Control Center Ain Shams University Hospitals between July and December 2022. Upon admission, all patients were followed up and had their levels of NT-proBNP, troponin I (cTnI), and creatine kinase myocardial band (CK-MB) analyzed.
RESULTS
Thirty patients were enrolled in the study and were divided into survivors and non-survivors. The initial NT-proBNP levels were significantly higher among non-survivors in contrast to the initial cTnI and CK-MB levels. The study identified that the best cutoff point of NT-proBNP for predicting mortality was ≥72 pg/ml, with AUC (0.869).
CONCLUSION
It can be concluded that NT-proBNP can serve as an early predictor of mortality in ALP poisoning.
背景
在埃及，磷化铝（ALP）是一种已知的致命毒药，因为它具有心脏毒性。本研究旨在评估 N 末端脑利钠肽前体（NT-proBNP）对 ALP 中毒患者死亡率的预测能力。
方法
本前瞻性研究于 2022 年 7 月至 12 月在艾因夏姆斯大学医院中毒控制中心收治的 ALP 中毒患者中进行。入院时，对所有患者进行随访，并分析其 NT-proBNP、肌钙蛋白 I（cTnI）和肌酸激酶心肌带（CK-MB）水平。
结果
本研究共纳入 30 例患者，并分为幸存者和非幸存者。与初始 cTnI 和 CK-MB 水平相比，非幸存者的初始 NT-proBNP 水平明显更高。研究发现，NT-proBNP 预测死亡率的最佳截断值为≥72 pg/ml，AUC（0.869）。
结论
可以得出结论，NT-proBNP 可作为 ALP 中毒患者死亡率的早期预测指标。
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