Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Adv Sci (Weinh). 2024 Nov;11(43):e2406439. doi: 10.1002/advs.202406439. Epub 2024 Sep 5.
Infected fracture healing is a complicated process that includes intricate interactions at the cellular and molecular levels. In addition to angiogenesis and osteogenesis, the significance of neurogenesis in fracture healing has also been recognized in recent years. Here, a nanocomposite hydrogel containing pH-responsive zinc-gallium-humic acids (HAs) nanoparticles is developed. Through the timed release of Zn, Ga, and HAs, the hydrogel exhibits potent antibacterial effects and promotes angiogenesis, osteogenesis, and neurogenesis. The enhanced neurogenesis further promotes angiogenesis and osteogenesis, forming a mutually supportive angiogenesis-osteogenesis-neurogenesis cycle at the fracture site. The hydrogel achieves rapid infected fracture healing and improves tissue regeneration in mice. This study proposes a comprehensive treatment approach that combines antibacterial effects with the regulation of tissue regeneration to improve infected fracture healing.
感染性骨折愈合是一个复杂的过程，包括细胞和分子水平上的复杂相互作用。近年来，神经发生在骨折愈合中的意义也得到了认识。在这里，开发了一种含有 pH 响应性锌镓-腐殖酸（HA）纳米粒子的纳米复合水凝胶。通过 Zn、Ga 和 HAs 的定时释放，水凝胶表现出强大的抗菌作用，并促进血管生成、成骨和神经发生。增强的神经发生进一步促进血管生成和成骨，在骨折部位形成相互支持的血管生成-成骨-神经发生循环。水凝胶实现了快速感染性骨折愈合，并改善了小鼠的组织再生。本研究提出了一种综合治疗方法，将抗菌作用与组织再生调节相结合，以改善感染性骨折愈合。
