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Blinatumomab is associated with better post-transplant outcome than chemotherapy in children with high-risk, first-relapse B-cell acute lymphoblastic leukemia irrespective of the conditioning regimen.

作者信息

Peters Christina, Bruno Angela, Rizzari Carmelo, Brescianini Alessandra, Von Stackelberg Arend, Linderkamp Christin, Zeng Yi, Zugmaier Gerhard, Locatelli Franco

机构信息

St. Anna Children's Hospital, St. Anna Children's Cancer Research Institute, University Vienna, Vienna.

Amgen Italia, Milan.

出版信息

Haematologica. 2025 Jan 1;110(1):234-238. doi: 10.3324/haematol.2024.285837.

DOI:10.3324/haematol.2024.285837
PMID:39234873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11694122/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/994a/11694122/65c8a4a3e1ff/110234.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/994a/11694122/65c8a4a3e1ff/110234.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/994a/11694122/65c8a4a3e1ff/110234.fig1.jpg

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Improved survival and MRD remission with blinatumomab vs. chemotherapy in children with first high-risk relapse B-ALL.与化疗相比，博纳吐单抗可提高首次高危复发B-ALL儿童的生存率并实现微小残留病缓解。
Leukemia. 2023 Jan;37(1):222-225. doi: 10.1038/s41375-022-01770-3. Epub 2022 Dec 8.
2
Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.基于全身照射的异基因 HSCT 后儿童 ALL 后续恶性肿瘤的发生率 - 前瞻性 ALL-SCT 2003 试验的长期随访。
Leukemia. 2022 Nov;36(11):2567-2576. doi: 10.1038/s41375-022-01693-z. Epub 2022 Sep 12.
3
Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Blinatumomab 与化疗治疗高危初发 B 细胞急性淋巴细胞白血病患儿无事件生存的效果：一项随机临床试验。
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Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.儿童 ALL 中全身放疗或化疗预处理：一项多国、随机、非劣效性 III 期研究。
J Clin Oncol. 2021 Feb 1;39(4):295-307. doi: 10.1200/JCO.20.02529. Epub 2020 Dec 17.
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Bone Marrow Transplant. 2020 Oct;55(10):1918-1927. doi: 10.1038/s41409-020-0806-8. Epub 2020 Jan 29.
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