Department of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium.
Department of Microbiology, Immunology & Transplantation, Nephrology & Renal Transplantation Research Group, KU Leuven, Belgium.
Biomark Med. 2024;18(17-18):787-794. doi: 10.1080/17520363.2024.2394383. Epub 2024 Sep 5.
Kidney transplantation is the most efficient renal replacement therapy. Current diagnostics for monitoring graft health are either invasive or lack precision. Metabolomics is an emerging discipline focused on the analysis of the small molecules involved in metabolism. Given the kidneys' central role in metabolic homeostasis and previous observations of altered metabolites correlating with restricted kidney graft function, metabolomics is highly promising for the discovery of novel biomarkers and the development of novel diagnostics. In this perspective, we summarize the known metabolic roles for the kidney, discuss biomarkers of graft health and immune status emerging from metabolomics research, and provide our perspective on how these and future findings can be integrated in clinical practice to enable precision diagnostics.
肾移植是最有效的肾脏替代疗法。目前用于监测移植物健康的诊断方法要么具有侵入性，要么缺乏准确性。代谢组学是一个新兴的学科，专注于分析代谢过程中涉及的小分子。鉴于肾脏在代谢稳态中的核心作用，以及先前观察到的代谢物改变与肾移植功能受限相关，代谢组学在发现新的生物标志物和开发新的诊断方法方面具有广阔的前景。在这篇观点文章中，我们总结了肾脏的已知代谢作用，讨论了代谢组学研究中出现的与移植物健康和免疫状态相关的生物标志物，并就如何将这些及未来的发现整合到临床实践中以实现精准诊断提供了我们的观点。
