Suneja Priya, Nambiar Kaniyappan, Tanveer Nadeem, Diwaker Preeti, Kumari Raushan, Gandhi Vijay
Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi University, New Delhi, Delhi, India.
Department of Dermatology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi University, New Delhi, Delhi, India.
Diagn Cytopathol. 2025 Jan;53(1):E1-E4. doi: 10.1002/dc.25402. Epub 2024 Sep 5.
Mastocytosis is characterized by the proliferation of neoplastic mast cells in various organs, which can have either cutaneous or systemic presentation. Solitary cutaneous mastocytomas are most commonly seen in the pediatric age group but rarely present in adults. Histopathology of cutaneous mastocytoma is well described in the literature but only a few studies are available describing the cytomorphological features. We present a case of a 19-year-old female who presented with a 6-month history of a right supraclavicular single, 0.5 × 0.5 cm, well-defined, reddish-brown round nodule. The fine needle aspiration cytology (FNAC) smears were highly cellular showing monomorphic cells, predominantly dispersed singly and occasionally in small clusters. The cells were round to oval, with moderate cytoplasm containing coarse metachromatic granules. Toluidine blue stain and CD117 immunocytochemical stain confirmed the presence of mast cell granules. Based on the cytomorphology, staining, clinical history, and examination, a diagnosis of solitary cutaneous mastocytoma was rendered. FNAC plays a pivotal role in diagnosing mast cell tumors and even obviates the need for tissue biopsy in selected cases.
肥大细胞增多症的特征是肿瘤性肥大细胞在各个器官中增殖，可表现为皮肤型或系统型。孤立性皮肤肥大细胞瘤最常见于儿童年龄组，但在成人中很少出现。皮肤肥大细胞瘤的组织病理学在文献中有详细描述，但仅有少数研究描述了其细胞形态学特征。我们报告一例19岁女性患者，其右锁骨上有一个6个月病史的单发、0.5×0.5厘米、边界清晰、红棕色圆形结节。细针穿刺抽吸细胞学（FNAC）涂片细胞丰富，显示单一形态的细胞，主要单个分散，偶尔成小簇状。细胞呈圆形至椭圆形，胞质中等，含有粗大的异染颗粒。甲苯胺蓝染色和CD117免疫细胞化学染色证实存在肥大细胞颗粒。根据细胞形态学、染色、临床病史和检查，诊断为孤立性皮肤肥大细胞瘤。FNAC在诊断肥大细胞肿瘤中起关键作用，甚至在某些病例中无需进行组织活检。
