Scalzo F M, Spear L P
Psychopharmacology (Berl). 1985;85(3):271-6. doi: 10.1007/BF00428186.
The effects of chronic haloperidol administration during the prenatal and preweanling periods on dopamine autoreceptor function were examined in striatum, olfactory tubercles, and nucleus accumbens of young (2-3 month) and older (12-13 month) adult rats. In striatum of young and older adult rats that had been chronically treated with haloperidol early in life, as well as in the nucleus accumbens of older adults receiving early chronic haloperidol, gamma-butyrolactone (GBL) did not induce significant increases in dopamine levels. In olfactory tubercles of young adults that had received early chronic treatment with haloperidol, apomorphine pretreatment failed to reverse the observed GBL-induced increase in dopamine levels. Thus, dopamine autoreceptor function appears to be attenuated in rats chronically treated with haloperidol during early development, in contrast to reports of autoreceptor supersensitivity following neuroleptic treatment in adulthood.
研究了产前和断奶前长期给予氟哌啶醇对幼龄（2 - 3个月）和成年（12 - 13个月）大鼠纹状体、嗅结节和伏隔核中多巴胺自身受体功能的影响。在幼年和成年大鼠的纹状体中，这些大鼠在生命早期接受了氟哌啶醇的长期治疗，以及在接受早期氟哌啶醇长期治疗的成年大鼠的伏隔核中，γ-丁内酯（GBL）并未引起多巴胺水平的显著升高。在幼年大鼠的嗅结节中，这些大鼠接受了早期氟哌啶醇的长期治疗，阿扑吗啡预处理未能逆转观察到的GBL诱导的多巴胺水平升高。因此，与成年期接受抗精神病药物治疗后自身受体超敏反应的报道相反，在早期发育过程中接受氟哌啶醇长期治疗的大鼠中，多巴胺自身受体功能似乎减弱。
