Woo S K, Hitzemann R J, Loh H H
Psychopharmacology (Berl). 1985;85(3):371-6. doi: 10.1007/BF00428204.
Bilateral microinjection of morphine (0.003-3 micrograms/side) into the caudate putamen enhances the behavior induced by the IP injection of 1 mg/kg d-amphetamine phosphate in a dose-related manner. The duration of activity was prolonged and ambulation was changed to d-amphetamine stereotypy, a behavior normally associated with higher doses of d-amphetamine. The opioid activity was stereospecific in that levorphanol was active, whereas dextrorphan was not. The enhancement of d-amphetamine-induced behavior by the opioids was blocked by naloxone. D-ala2-met-Enkephalin also enhanced the amphetamine-induced behavior. This enhancement appears to be specific to the caudate putamen because the oral stereotypy observed appears to be a unique action of amphetamine in this region of the brain.
双侧尾状壳核微量注射吗啡（每侧0.003 - 3微克），以剂量相关的方式增强了腹腔注射1毫克/千克磷酸右旋苯丙胺所诱发的行为。活动持续时间延长，走动转变为右旋苯丙胺刻板行为，这是一种通常与较高剂量右旋苯丙胺相关的行为。阿片类活性具有立体特异性，即左啡诺有活性，而右啡烷无活性。阿片类药物对右旋苯丙胺诱发行为的增强作用被纳洛酮阻断。D -丙氨酸2 - 甲硫氨酸脑啡肽也增强了苯丙胺诱发的行为。这种增强作用似乎对尾状壳核具有特异性，因为所观察到的口腔刻板行为似乎是苯丙胺在大脑该区域的独特作用。
