Mittleman G, Jones G H, Robbins T W
Department of Experimental Psychology, University of Cambridge, England.
Behav Neural Biol. 1991 Sep;56(2):170-82. doi: 10.1016/0163-1047(91)90584-d.
The potential coping functions of amphetamine-induced stereotypy were investigated using a physiological index of stress or arousal, plasma corticosterone level. A series of five injections of d-amphetamine was used to enhance stereotyped behavior in control animals as well as in rats with bilateral dopamine-depleting lesions of the caudate-putamen. This regimen of amphetamine injections significantly increased stereotyped behavior and also reduced the normal elevation in corticosterone produced by treatment with d-amphetamine. This effect was apparent in both control and lesioned animals. These results support the hypothesis that amphetamine-induced stereotyped behavior functions to reduce stress or arousal and additionally suggest that this effect is largely independent of underlying dopaminergic mechanisms.
利用应激或唤醒的生理指标——血浆皮质酮水平，研究了苯丙胺诱导的刻板行为的潜在应对功能。对对照动物以及尾状核-壳核双侧多巴胺耗竭损伤的大鼠，使用一系列五次注射d-苯丙胺来增强刻板行为。这种苯丙胺注射方案显著增加了刻板行为，同时也降低了d-苯丙胺治疗所产生的皮质酮正常升高水平。这种效应在对照动物和损伤动物中均很明显。这些结果支持了以下假设：苯丙胺诱导的刻板行为起到减轻应激或唤醒的作用，此外还表明这种效应在很大程度上独立于潜在的多巴胺能机制。
