接受替加环素和同时使用 5-羟色胺能药物的患者发生 5-羟色胺综合征的发生率。
Incidence of serotonin syndrome in patients receiving tedizolid and concomitant serotonergic agents.
机构信息
Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
出版信息
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0087024. doi: 10.1128/aac.00870-24. Epub 2024 Sep 5.
Abstract
This study investigated the real-world incidence rate of serotonin syndrome in patients receiving tedizolid and concomitant serotonergic agents. A retrospective cohort of 479 adult patients was assessed between January 2015 and July 2023. Overall, a rare rate of 0.4% (2/479) of possible serotonin syndrome with tedizolid was identified. Given that concomitant serotonergic agents were commonly used, further study is warranted to determine causality.
摘要
本研究调查了接受替加环素和同时使用 5-羟色胺能药物的患者中真实世界的 5-羟色胺综合征发生率。在 2015 年 1 月至 2023 年 7 月期间，对 479 名成年患者进行了回顾性队列研究。总体而言，替加环素引起可能的 5-羟色胺综合征的罕见率为 0.4%（2/479）。鉴于同时使用 5-羟色胺能药物很常见，需要进一步研究以确定因果关系。
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