Hiller Wolf, Grabe Bastian, Schonert Jan
Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Anal Chem. 2024 Sep 17;96(37):14902-14908. doi: 10.1021/acs.analchem.4c02874. Epub 2024 Sep 5.
The development of the most comprehensive universal calibration of molar mass dependences will be presented. For the first time, diffusion-ordered spectroscopy (DOSY) can now provide structure-, solvent-, and temperature-independent molar mass determinations for both small and large molecules. This fundamental theoretical approach provides only one single function which could perfectly describe all molar mass dependences. The new development using DOSY was tested on 477 diffusion coefficients representing altogether 56 molar mass dependences of 30 small molecules in 7 solvents, 5 different polymers in 10 solvents, and 11 temperature dependences of 2 polymers in 2 solvents, respectively. These samples cover a very large range of molar masses varying between 70 g/mol until 1 200 000 g/mol. The derived equation for the molar masses delivered a very good accuracy for all samples and might be one of the best tools for molar mass determinations.
将介绍最全面的摩尔质量相关性通用校准方法的进展。扩散排序光谱法（DOSY）首次能够为小分子和大分子提供与结构、溶剂和温度无关的摩尔质量测定。这种基本的理论方法仅提供一个单一函数，该函数可以完美描述所有摩尔质量相关性。使用DOSY的新进展分别在477个扩散系数上进行了测试，这些扩散系数总共代表了7种溶剂中30个小分子的56种摩尔质量相关性、10种溶剂中5种不同聚合物的摩尔质量相关性以及2种溶剂中2种聚合物的11种温度相关性。这些样品涵盖了非常大的摩尔质量范围，从70 g/mol到1200000 g/mol不等。推导出的摩尔质量方程对所有样品都具有非常高的准确性，可能是摩尔质量测定的最佳工具之一。
