Song Suting, Hu Qu, Du Jiayi, Yan Sisi, Lei Xuejiao, Tang Ruisi, Wang Chunyu
Radiation Oncology Center, Chongqing University Cancer Hospital, No. 181 Han Yu Road, Shapingba District, Chongqing, 400030, China.
Clin Transl Oncol. 2025 Apr;27(4):1738-1747. doi: 10.1007/s12094-024-03699-8. Epub 2024 Sep 5.
To examine the prevalence of cancer-related cognitive impairment (CRCI) and its contributing factors in patients with nasopharyngeal carcinoma (NPC) and explore the relationship between various assessment methods.
A cross-sectional study was conducted with 367 patients with NPC between March 2022 and April 2024 at Chongqing University Cancer Hospital. The data gathered from the demographic questionnaire, Montreal Cognitive Assessment (MoCA), Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) were analyzed using logistic regression.
Out of 367 participants, males accounted for 271 (73.84%). There were 217 (59.13%) individuals aged between 35-55 years. Cognitive impairment incidence was 58.04% using MoCA and 47.98% using FACT-Cog. Years of education, work condition, age and time since diagnosis (≥ 11 months) were all significantly associated with cognitive impairment using MoCA, the strongest being time since diagnosis (≥ 11 months) (OR = 2.672, 95% CI = 1.191-5.997, P = 0.017). Gender, marital status (married), place of residence (township), place of residence (city), alcohol history, SAS and SDS were all significantly associated with FACT-Cog, the strongest being marital status (married) (OR = 4.100, 95% CI = 1.130-14.87, P = 0.032).
Patients diagnosed with NPC exhibit susceptibility to CRCI. There was a weak correlation between some aspects of the subjective tests and the objective test scores. Advanced age and disease diagnosis longer than 10 months are associated with a heightened risk of objective cognitive impairment. Furthermore, residing in rural areas, female, married, alcohol history, SAS and SDS increases the likelihood of subjective cognitive impairment. These findings highlight the need to select appropriate assessment scales for different needs and take targeted interventions to address CRCI in patients with NPC.
探讨鼻咽癌（NPC）患者中癌症相关认知障碍（CRCI）的患病率及其影响因素，并探索各种评估方法之间的关系。
于2022年3月至2024年4月在重庆大学附属肿瘤医院对367例NPC患者进行了一项横断面研究。使用逻辑回归分析从人口统计学调查问卷、蒙特利尔认知评估（MoCA）、癌症治疗认知功能功能评估（FACT-Cog）、自评焦虑量表（SAS）和自评抑郁量表（SDS）收集的数据。
367名参与者中，男性占271名（73.84%）。年龄在35 - 55岁之间的有217名（59.13%）。使用MoCA评估的认知障碍发生率为58.04%，使用FACT-Cog评估的为47.98%。受教育年限、工作状况、年龄和确诊时间（≥11个月）均与使用MoCA评估的认知障碍显著相关，其中确诊时间（≥11个月）相关性最强（OR = 2.672，95%CI = 1.191 - 5.997，P = 0.017）。性别、婚姻状况（已婚）、居住地点（乡镇）、居住地点（城市）、饮酒史、SAS和SDS均与FACT-Cog显著相关，其中婚姻状况（已婚）相关性最强（OR = 4.100，95%CI = 1.130 - 14.87，P = 0.032）。
确诊为NPC的患者易患CRCI。主观测试的某些方面与客观测试分数之间存在弱相关性。高龄和确诊疾病超过10个月与客观认知障碍风险增加相关。此外，居住在农村地区、女性、已婚、有饮酒史、SAS和SDS会增加主观认知障碍的可能性。这些发现凸显了根据不同需求选择合适评估量表以及采取针对性干预措施来解决NPC患者CRCI问题的必要性。
