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不同阑尾残端闭合方法在腹腔镜阑尾切除术中的效果:一项网状Meta 分析。

Effectiveness of different appendiceal stump closure methods in laparoscopic appendectomy a network meta-analysis.

机构信息

Faculty of Medicine, Elmergib University, Al-Khums, Libya.

Medical Research Group of Libya, Negida Academy, Arlington, MA, USA.

出版信息

Langenbecks Arch Surg. 2024 Sep 5;409(1):270. doi: 10.1007/s00423-024-03452-3.

DOI:10.1007/s00423-024-03452-3
PMID:39235593
Abstract

PURPOSE

Choosing the best stump closure method for laparoscopic appendectomy has been a debated issue, especially for patients with acute appendicitis. The lack of consensus in the literature and the diverse techniques available have prompted the need for a comprehensive evaluation to guide surgeons in selecting the most optimal appendiceal stump closure method.

METHODS

A comprehensive search was conducted on multiple databases from inception until December 2023 to find relevant studies according to eligibility criteria. The primary outcome was the incidence of total complications.

RESULTS

25 studies with a total of 3308 patients were included in this study, overall complications did not reveal a significant advantage for any intervention (RR = 0.72, 95% CI: 0.53; 1.01), Superficial and deep infection risks were similar across all methods, Operative time was significantly longer with endoloop and Intracorporeal sutures (MD = 7.07, 95% CI: 3.28; 10.85) (MD = 26.1, 95% CI: 20.9; 31.29).

CONCLUSIONS

There are no significant differences in overall complications among closure methods. However, Intracorporeal sutures and endoloop techniques were associated with extended operative durations.

摘要

目的

选择最佳的腹腔镜阑尾切除术残端闭合方法一直是一个有争议的问题,特别是对于急性阑尾炎患者。文献中缺乏共识,并且有多种技术可供选择,这促使我们需要进行全面评估,以指导外科医生选择最合适的阑尾残端闭合方法。

方法

根据纳入标准,从创建到 2023 年 12 月,我们在多个数据库中进行了全面检索,以查找相关研究。主要结局是总并发症的发生率。

结果

本研究共纳入 25 项研究,共计 3308 例患者。总体并发症并没有显示任何干预措施有显著优势(RR=0.72,95%CI:0.53;1.01)。所有方法的浅表和深部感染风险相似,而使用 Endoloop 和体内缝合的手术时间明显更长(MD=7.07,95%CI:3.28;10.85)(MD=26.1,95%CI:20.9;31.29)。

结论

各种闭合方法之间的总并发症没有显著差异。然而,体内缝合和 Endoloop 技术与手术时间延长有关。

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本文引用的文献

1
Advantages of using a polymeric clip versus an endoloop during laparoscopic appendectomy in uncomplicated appendicitis: a randomized controlled study.在单纯性阑尾炎腹腔镜阑尾切除术中使用聚合物夹与 Endoloop 相比的优势:一项随机对照研究。
World J Emerg Surg. 2023 Jun 29;18(1):39. doi: 10.1186/s13017-023-00507-6.
2
A guide and pragmatic considerations for applying GRADE to network meta-analysis.将GRADE应用于网状Meta分析的指南及实际考量
BMJ. 2023 Jun 27;381:e074495. doi: 10.1136/bmj-2022-074495.
3
A randomized clinical trial of technical modifications of appendix stump closure during laparoscopic appendectomy for uncomplicated acute appendicitis.
腹腔镜阑尾切除术治疗单纯性急性阑尾炎时阑尾残端闭合技术改良的随机临床试验
BMC Surg. 2021 May 31;21(1):272. doi: 10.1186/s12893-021-01279-z.
4
GRADE approach to drawing conclusions from a network meta-analysis using a minimally contextualised framework.使用最小化情境化框架从网络荟萃分析得出结论的GRADE方法。
BMJ. 2020 Nov 11;371:m3900. doi: 10.1136/bmj.m3900.
5
Closure of the appendiceal stump in laparoscopic appendectomy: A systematic review of the literature.腹腔镜阑尾切除术中阑尾残端的闭合:文献系统综述
Ann Med Surg (Lond). 2020 Aug 4;57:228-235. doi: 10.1016/j.amsu.2020.07.058. eCollection 2020 Sep.
6
Hem-o-lok clips versus intracorporeal knotting for the closure of the appendix stump in laparoscopic appendectomy: A prospective randomized study.腹腔镜阑尾切除术中使用Hem-o-lok夹与体内打结法闭合阑尾残端的前瞻性随机研究
Ulus Travma Acil Cerrahi Derg. 2020 May;26(3):384-388. doi: 10.14744/tjtes.2019.02248.
7
Are endoscopic loop ties safe even in complicated acute appendicitis? A systematic review and meta-analysis.内镜套扎环结扎术在复杂急性阑尾炎中安全吗?系统评价和荟萃分析。
Int J Surg. 2019 Aug;68:40-47. doi: 10.1016/j.ijsu.2019.06.011. Epub 2019 Jun 18.
8
The use of polymeric clips in securing the appendiceal stump during laparoscopic appendicectomy: a systematic review.在腹腔镜阑尾切除术中使用聚合物夹固定阑尾残端:系统评价。
Eur J Trauma Emerg Surg. 2019 Aug;45(4):665-670. doi: 10.1007/s00068-019-01105-5. Epub 2019 Feb 28.
9
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Cochrane Database Syst Rev. 2017 Nov 13;11(11):CD006437. doi: 10.1002/14651858.CD006437.pub3.
10
The influence of the different forms of appendix base closure on patient outcome in laparoscopic appendectomy: a randomized trial.不同形式的阑尾根部闭合方式对腹腔镜阑尾切除术患者结局的影响:一项随机试验。
Surg Endosc. 2018 May;32(5):2295-2299. doi: 10.1007/s00464-017-5924-z. Epub 2017 Nov 2.