利用 CRISPR-Combo 系统在番茄中进行正交基因组编辑和转录激活。
Orthogonal genome editing and transcriptional activation in tomato using CRISPR-Combo systems.
机构信息
Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD, USA.
Department of Horticulture, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
出版信息
Plant Cell Rep. 2024 Sep 5;43(9):227. doi: 10.1007/s00299-024-03316-6.
PMID:39235647
Abstract
The CRISPR-Combo systems (Cas9-Combo and CBE-Combo) are designed for comprehensive genetic manipulation, enabling Cas9-based targeted mutagenesis or cytosine base editing with simultaneous gene activation in tomato stable lines.
摘要
CRISPR-Combo 系统（Cas9-Combo 和 CBE-Combo）旨在进行全面的基因操作，可在番茄稳定系中实现基于 Cas9 的靶向诱变或胞嘧啶碱基编辑，同时进行基因激活。
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