Jhanji Kanika, Shivji Zaitoon, Lazaj Marion, Lomax Lysa Boisse, Winston Gavin P, Shukla Garima
Division of Neurology, Department of Medicine, Queen's University and Kingston Health Sciences Center, Kingston, Ontario, Canada.
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Epileptic Disord. 2024 Dec;26(6):779-786. doi: 10.1002/epd2.20276. Epub 2024 Sep 5.
Very few publications have reported the impact of artisanal cannabis use on overall quality of life among people with drug-resistant epilepsy. This study aimed to evaluate the association of artisanal cannabis use among adults with drug-resistant epilepsy with quality of life, and to determine if an association exists between Quality-of-Life in Epilepsy Inventory-31 (QOLIE-31) 'T scores' and different clinical variables.
This study included patients admitted to a Canadian tertiary care epilepsy center as part of a larger study. These patients were confirmed to have drug-resistant epilepsy by an epileptologist at the Ambulatory Epilepsy Clinic. Patients were categorized into cannabis users (CAN group) (n = 25) and Non-cannabis users (Non-CAN group) (n = 21). Data was collected on RedCap® for epilepsy and cannabis use details. These were analyzed for an association using a binary multivariable logistic regression model between QOLIE-31 'T scores' and age, sex, epilepsy duration, age at initiation of use, duration of cannabis use and psychiatric related comorbidity for all patients. Additionally, different 'T subscores' of the questionnaire were compared between the CAN group and Non-CAN group.
A statistically significant difference between the CAN group and Non-CAN group for the T subscore 'energy and fatigue' (p = .004) was found, with the CAN group scoring higher. However, for the 'overall T score' between the two groups there was no statically significant difference (p = .11). Additionally, a significant negative correlation between 'overall T score' and cannabis use disorder (p = .032) was found.
This study provides new data on association of quality of life in epilepsy with cannabis use and can serve as a foundation for larger future studies to better assess this association.
极少有出版物报道过使用自制大麻对耐药性癫痫患者总体生活质量的影响。本研究旨在评估成年耐药性癫痫患者使用自制大麻与生活质量之间的关联，并确定癫痫生活质量量表-31（QOLIE-31）“T分数”与不同临床变量之间是否存在关联。
本研究纳入了作为一项更大规模研究的一部分而入住加拿大一家三级护理癫痫中心的患者。这些患者在门诊癫痫诊所经癫痫专家确诊患有耐药性癫痫。患者被分为大麻使用者（CAN组）（n = 25）和非大麻使用者（非CAN组）（n = 21）。通过RedCap®收集癫痫和大麻使用细节的数据。使用二元多变量逻辑回归模型对所有患者的QOLIE-31“T分数”与年龄、性别、癫痫病程、开始使用大麻的年龄、大麻使用时长以及精神相关合并症之间的关联进行分析。此外，还比较了CAN组和非CAN组之间问卷不同的“T子分数”。
发现CAN组和非CAN组在“精力与疲劳”T子分数上存在统计学显著差异（p = 0.004），CAN组得分更高。然而，两组之间的“总体T分数”没有统计学显著差异（p = 0.11）。此外，发现“总体T分数”与大麻使用障碍之间存在显著负相关（p = 0.032）。
本研究提供了关于癫痫生活质量与大麻使用之间关联的新数据，可为未来规模更大的研究奠定基础，以更好地评估这种关联。
