Precision medicine center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
Precision medicine center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Department of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
J Affect Disord. 2024 Dec 15;367:174-183. doi: 10.1016/j.jad.2024.09.009. Epub 2024 Sep 3.
This study aimed to investigate the interplay between genetic susceptibility and socioeconomic disparities on psychiatric disorders.
In this study, we utilized data from the UK Biobank to analyze the Generalized Anxiety Disorder (GAD)-7 scale (N = 74,425) and the Patient Health Questionnaire (PHQ)-9 (N = 74,101), along with the Index of Multiple Deprivation (IMD). The polygenic risk score (PRS) was calculated to assess the genetic risk associated with GAD-7/PHQ-9 scores, and the individuals were classified into low, medium, and high genetic risk groups according to tertiles of PRSs related to the GAD-7/PHQ-9. Linear regression models were used to explore the relationships between GAD-7/PHQ-9 scores and IMD scores in patients with different genetic susceptibilities.
Disadvantaged socioeconomic status was associated with the risk of anxiety and depression across all strata of genetic risk, and stronger associations were shown for individuals with greater genetic susceptibility. From low to high genetic risk, the risk of psychiatric disorders increased for the GAD-7 (β = 0.002 to 0.032) and PHQ-9 (β = 0.003 to 0.045) scores. In addition, strong associations of high genetic risk with anxiety (β = 0.875) and depression (β = 1.152) were detected in the IMD quartile 4 group compared with the least deprivation quartile group. Furthermore, income and employment were estimated to contribute strongly to anxiety (β = 7.331, β = 4.492) and depression (β = 9.951, β = 6.453) in the high genetic risk group.
The results suggest that we should pay more attention to psychiatric disorders with high genetic susceptibility and try to improve their socioeconomic status to prevent the development of psychiatric disorders.
本研究旨在探讨遗传易感性与社会经济差异在精神障碍中的相互作用。
本研究利用英国生物库的数据，分析了广泛性焦虑障碍 7 项量表（GAD-7）（N=74425）和患者健康问卷 9 项量表（PHQ-9）（N=74101）以及剥夺指数（IMD）。计算多基因风险评分（PRS）以评估与 GAD-7/PHQ-9 评分相关的遗传风险，根据与 GAD-7/PHQ-9 相关的 PRS 的三分位数将个体分为低、中、高遗传风险组。采用线性回归模型探讨不同遗传易感性患者 GAD-7/PHQ-9 评分与 IMD 评分之间的关系。
不利的社会经济地位与所有遗传风险分层的焦虑和抑郁风险相关，且遗传易感性较高的个体关联更强。从低到高遗传风险，GAD-7（β=0.002 至 0.032）和 PHQ-9（β=0.003 至 0.045）评分的精神障碍风险增加。此外，与最贫困四分位数组相比，高遗传风险组与 IMD 四分位数 4 组的焦虑（β=0.875）和抑郁（β=1.152）存在较强关联。此外，在高遗传风险组中，收入和就业被估计对焦虑（β=7.331，β=4.492）和抑郁（β=9.951，β=6.453）有很强的贡献。
结果表明，我们应更加关注遗传易感性高的精神障碍，并努力改善其社会经济地位，以预防精神障碍的发生。
