Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Department of Statistics, College of Science, Wuhan University of Technology, Wuhan, 430070, China.
J Affect Disord. 2024 Dec 15;367:342-349. doi: 10.1016/j.jad.2024.09.012. Epub 2024 Sep 3.
Previous studies reported the effect of physical activity (PA) or sedentary behavior (SB) on increasing occurrence of depression in patients with cardiovascular disease, leading to a higher risk of adverse clinical outcomes. However, the association between the combination of PA and SB and depression in patients with cardiovascular disease remained unstudied.
Patients with cardiovascular disease (aged ≥18 years) who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. Multivariable logistic regression was used to investigate the association between PA, SB, and depression.
Among the 2585 patients (mean age 64.43 years; 54.65 % male) in this study, the prevalence of depression was 16.40 %. After adjustment for age, gender, race, education level, marital status, poverty income ratio, employment status, smoking, alcohol use, BMI, hypertension, and number of cardiovascular diseases, depression was negatively associated with higher PA (adjusted OR = 0.567, 95 % CI 0.403, 0.799) and positively associated with higher SB (adjusted OR = 1.472, 95 % CI 1.089, 1.990), respectively. The risk of depression associated with higher PA and lower SB was significantly lower (adjusted OR = 0.464, 95 % CI 0.307, 0.702) compared to those with lower PA but higher SB.
This was a cross-sectional study with limited ability to make causal inferences.
Our findings indicate that patients with higher PA and lower SB have a lower risk of depression than those with low PA levels and high SB levels. Moving more and sitting less is a potential preventive measure against depression in patients with cardiovascular disease.
先前的研究报告称，身体活动（PA）或久坐行为（SB）会增加心血管疾病患者的抑郁发生，从而导致不良临床结局的风险增加。然而，PA 和 SB 相结合与心血管疾病患者抑郁之间的关联仍未得到研究。
本研究纳入了参加 2007 年至 2016 年国家健康和营养调查（NHANES）的心血管疾病患者（年龄≥18 岁）。采用多变量逻辑回归来研究 PA、SB 与抑郁之间的关系。
在这项研究的 2585 名患者（平均年龄 64.43 岁；54.65%为男性）中，抑郁的患病率为 16.40%。在校正年龄、性别、种族、教育程度、婚姻状况、贫困收入比、就业状况、吸烟、饮酒、BMI、高血压和心血管疾病数量后，抑郁与较高的 PA（校正 OR=0.567，95%CI 0.403，0.799）呈负相关，与较高的 SB（校正 OR=1.472，95%CI 1.089，1.990）呈正相关。与较低 PA 和较高 SB 相关的抑郁风险明显较低（校正 OR=0.464，95%CI 0.307，0.702），与那些 PA 较低但 SB 较高的患者相比。
这是一项横断面研究，因果推断能力有限。
我们的研究结果表明，PA 较高且 SB 较低的患者患抑郁的风险低于 PA 水平较低且 SB 水平较高的患者。多运动、少坐是预防心血管疾病患者抑郁的一种潜在措施。
