Yang Chun, Gao Tiankuo, Zhang Yichen, Feng Cuicui, Zhang Kai
Beijing Anzhen hospital, Capital Medical University, Beijing, China.
Longyan University, Longyan, China.
Brain Behav. 2025 Jun;15(6):e70615. doi: 10.1002/brb3.70615.
Earlier studies have proposed the effect of education level and sedentary behavior (SB) on the incidence of depression in adults. However, the association between the combination of education level and SB and depression in adults has not yet been investigated.
This study population consisted of US adults (aged ≥18 years) who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A multivariable logistic regression model was employed to assess the association between education level, SB, and depression.
Of the 29,822 participants (weighted mean [SE] age, 47.9[0.2] years; 51.2% male) in our study cohort. Depression was negatively linked to the higher education level (adjusted OR = 0.68 [95% CI: 0.57-0.81], Model 4) and positively correlated to higher SB (adjusted OR = 1.58 [95% CI: 1.34-1.87]). The ORs [95% CIs] for depression were 1.40 [1.13-1.74], 1.68 [1.20-2.35], and 1.78 [1.42-2.22], respectively, among lower education groups sitting < 6 h a day (h/d), 6-8 h/d and ≥ 8 h/d compared with higher education/ sitting < 6 h/d groups (Model 3). Among participants with higher education, those who engaged in SB ≥ 8 h/d had a 1.53-fold [95% CI, 1.31-1.79] increased risk of depression compared with those who sat for <6 h/d (p < 0.0001; Model 4).
A lower education level and prolonged SB are independently and jointly associated with an increased risk of depression. Interventions that aim to reduce SB, especially among those with lower educational levels and also among those with higher educational levels who sit for more than 8 h per day, may help reduce the prevalence of depression.
早期研究提出了教育水平和久坐行为（SB）对成年人抑郁症发病率的影响。然而，教育水平和久坐行为的组合与成年人抑郁症之间的关联尚未得到研究。
本研究人群包括2007年至2018年参加美国国家健康和营养检查调查（NHANES）的美国成年人（年龄≥18岁）。采用多变量逻辑回归模型评估教育水平、久坐行为和抑郁症之间的关联。
在我们的研究队列中的29822名参与者（加权平均[SE]年龄，47.9[0.2]岁；51.2%为男性）中。抑郁症与较高的教育水平呈负相关（调整后的OR = 0.68 [95% CI：0.57 - 0.81]，模型4），与较高的久坐行为呈正相关（调整后的OR = 1.58 [95% CI：1.34 - 1.87]）。与高等教育/每天久坐<6小时组相比，低教育组每天久坐<6小时（h/d）、6 - 8小时/d和≥8小时/d的抑郁症OR [95% CI]分别为1.40 [1.13 - 1.74]、1.68 [1.20 - 2.35]和1.78 [1.42 - 2.22]（模型3）。在高等教育参与者中，每天久坐≥8小时的人与每天久坐<6小时的人相比，患抑郁症的风险增加了1.53倍[95% CI，1.31 - 1.79]（p < 0.0001；模型4）。
较低的教育水平和长时间的久坐行为独立且共同与抑郁症风险增加相关。旨在减少久坐行为的干预措施，特别是在教育水平较低的人群以及每天久坐超过8小时的高教育水平人群中，可能有助于降低抑郁症的患病率。
