Department of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Department of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Life Sci. 2024 Nov 1;356:123034. doi: 10.1016/j.lfs.2024.123034. Epub 2024 Sep 3.
Collagen and hyaluronic acid are essential components of the dermis that collaborate to maintain skin elasticity and hydration due to their unique biochemical properties and interactions within the extracellular matrix. Prolonged exposure to glucocorticoids can induce skin aging, which manifests as diminished collagen content and hyaluronic acid levels in the dermis. Nerol, a monoterpene alcohol found in essential oils, was examined in this study for its potential to counteract glucocorticoid-induced skin aging and the underlying mechanism behind its effects. Our findings reveal that non-toxic concentrations of nerol treatment can reinstate collagen content and hyaluronic acid levels in human dermal fibroblasts treated with dexamethasone. Mechanistically, nerol mitigates dexamethasone-induced oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The protective effects of nerol were significantly abrogated when the Nrf2 pathway was inhibited using the specific inhibitor ML385. In conclusion, nerol protects human dermal fibroblasts against glucocorticoid-induced skin aging by ameliorating oxidative stress via activation of the Nrf2 pathway, thereby highlighting its potential as a therapeutic agent for preventing and treating glucocorticoid-induced skin aging.
胶原蛋白和透明质酸是真皮的重要组成部分，由于其独特的生化特性和细胞外基质中的相互作用，共同维持皮肤的弹性和水分。长期暴露于糖皮质激素会导致皮肤老化，表现为真皮中胶原蛋白含量和透明质酸水平降低。在这项研究中，我们研究了单萜醇橙花醇是否具有抵抗糖皮质激素诱导的皮肤老化的潜力及其作用机制。我们的研究结果表明，橙花醇的无毒浓度治疗可以恢复用地塞米松处理的人真皮成纤维细胞中的胶原蛋白含量和透明质酸水平。从机制上讲，橙花醇通过激活核因子红细胞 2 相关因子 2（Nrf2）信号通路来减轻地塞米松诱导的氧化应激。当使用特定抑制剂 ML385 抑制 Nrf2 通路时，橙花醇的保护作用明显被阻断。总之，橙花醇通过激活 Nrf2 通路改善氧化应激来保护人真皮成纤维细胞免受糖皮质激素诱导的皮肤老化，从而突出了其作为预防和治疗糖皮质激素诱导的皮肤老化的治疗剂的潜力。
