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Tanner 靶身高公式低估了韩国青少年和年轻人的最终成人身高:基于 2010-2019 年韩国国家健康和营养检查调查的靶身高重新评估。

Tanner's target height formula underestimates final adult height in Korean adolescents and young adults: reassessment of target height based on the Korean National Health and Nutrition Examination Survey 2010-2019.

机构信息

Department of Pediatrics, Dong-A University College of Medicine, Busan, Busan, Korea (the Republic of).

Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Busan, Korea (the Republic of)

出版信息

BMJ Paediatr Open. 2024 Sep 4;8(1):e002653. doi: 10.1136/bmjpo-2024-002653.

Abstract

OBJECTIVE

Estimating children's target height (TH) plays an important role in diagnosing, evaluating and treating many paediatric endocrinological diseases. However, in many countries, employing Tanner's formula to predict children's final adult height (FAH) is considered misleading. Therefore, this study aimed to re-evaluate the validity of Tanner's formula for predicting the TH of Korean adolescents and young adults and develop a new formula suitable for Korean children.

DESIGN/SETTING: Data were derived from the Korean National Health and Nutrition Examination Survey 2010-2019.

PATIENTS

A total of 2586 participants (1266 men, 1320 women) were included, excluding participants for whom Tanner's formula could not be calculated because of missing parental height data.

MAIN OUTCOME MEASURES

Tanner-based TH was compared with the FAH.

RESULTS

The difference between Tanner-based TH and FAH was 4.86±0.178 cm for men and 4.81±0.150 cm for women. Sex-specific univariable and multivariable analyses were conducted to determine variables influencing positive height gap (greater than estimated TH). Both men and women with higher education levels were more likely to exhibit a positive height gap. Those with a history of chronic illness were less likely to exhibit a positive height gap, particularly in women. Using a new formula derived using linear regression analysis, the sum of parental heights explained 27.6% and 30.6% of the variance in sons' and daughters' heights, respectively.

CONCLUSIONS

Tanner's formula for calculating TH tended to underestimate FAH; hence, our new formula may offer a better alternative for estimating TH and evaluating growth in Korean children and adolescents.

摘要

目的

估算儿童的靶身高(TH)在诊断、评估和治疗许多儿科内分泌疾病中起着重要作用。然而,在许多国家,使用 Tanner 公式预测儿童最终成人身高(FAH)被认为是有误导性的。因此,本研究旨在重新评估 Tanner 公式预测韩国青少年和年轻成年人 TH 的有效性,并为韩国儿童开发一种新的适用公式。

设计/设置:数据来自 2010-2019 年韩国国家健康和营养检查调查。

患者

共纳入 2586 名参与者(男性 1266 名,女性 1320 名),排除因父母身高数据缺失而无法计算 Tanner 公式的参与者。

主要观察指标

比较基于 Tanner 的 TH 与 FAH。

结果

男性的 Tanner 基于 TH 与 FAH 的差异为 4.86±0.178cm,女性为 4.81±0.150cm。进行了性别特异性单变量和多变量分析,以确定影响正身高差距(大于估计的 TH)的变量。教育程度较高的男性和女性更有可能出现正身高差距。有慢性病史的人不太可能出现正身高差距,尤其是女性。使用线性回归分析得出的新公式,父母身高之和分别解释了儿子和女儿身高差异的 27.6%和 30.6%。

结论

计算 TH 的 Tanner 公式往往低估了 FAH;因此,我们的新公式可能为估计韩国儿童和青少年的 TH 以及评估生长提供更好的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8537/11381647/ce6e081b7096/bmjpo-8-1-g001.jpg

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