ANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France.
INRAE, UR 0045 Laboratoire de Recherches sur le Développement de l'Elevage (SELMET-LRDE), 20250, Corte, France.
Sci Rep. 2024 Sep 5;14(1):20674. doi: 10.1038/s41598-024-71539-4.
Tick-borne rickettsioses, caused by Gram-negative bacteria of the Rickettsia genus, pose a growing global threat, with various arthropod vectors contributing to their transmission. Understanding the complex interactions within tick microbiota, including the role of Rickettsia species, is crucial for elucidating the dynamics of rickettsial diseases. Here, we investigate the taxonomic profiles and co-occurrence networks of Rickettsia in Rh. sanguineus sensus lato (s.l.) and Rh. turanicus ticks, revealing significant differences in community composition and local connectivity of Rickettsia species. While the microbiota of both tick species share common taxa, distinct differences in relative abundance and network topology suggest unique ecological niches. Moreover, robustness analysis demonstrates varying resilience to perturbations, indicating different strategies for network organization. Our findings also highlight metabolic differences between tick species, suggesting potential implications for Rickettsia interactions. Overall, this study provides insights into the intricate microbial landscape within ticks, shedding light on the functional redundancy and metabolic pathways associated with Rickettsia, thus advancing our understanding of tick-borne diseases.
蜱传立克次体病由立克次体属革兰氏阴性细菌引起，对全球构成日益严重的威胁，各种节肢动物媒介有助于其传播。了解蜱微生物群中的复杂相互作用，包括立克次体物种的作用，对于阐明立克次体病的动态至关重要。在这里，我们研究了 Rh. sanguineus sensu lato（s.l.）和 Rh. turanicus 蜱中的立克次体的分类特征和共同发生网络，揭示了立克次体物种群落组成和局部连接性的显著差异。虽然两种蜱的微生物群都有共同的分类群，但相对丰度和网络拓扑结构的明显差异表明存在独特的生态位。此外，稳健性分析表明对扰动的抵抗力不同，表明网络组织的不同策略。我们的研究结果还强调了蜱种之间的代谢差异，表明这对立克次体相互作用可能具有潜在影响。总体而言，本研究深入了解了蜱内复杂的微生物景观，揭示了与立克次体相关的功能冗余和代谢途径，从而提高了我们对立克次体病的理解。
