Kim Jennifer Y, Florez Maria, Botto Emily, Belgrave Xoli, Grace Clare, Getz Ken
Tufts School of Medicine, Tufts Center for the Study of Drug Development, Boston, MA, USA.
Parexel, Durham, NC, USA.
Commun Med (Lond). 2024 Sep 5;4(1):172. doi: 10.1038/s43856-024-00586-9.
Characterizing perceptions of clinical trials among the socioeconomically disadvantaged is necessary for understanding how social determinants of health such as socioeconomic disparities in education and income can affect people's awareness of and exposure to clinical trials METHODS: A survey was distributed in spring 2023 among a survey taking sample stratified by demographic variables to reflect the U.S.
The survey assessed the socioeconomic status of the respondent and related covariates, as well as outcome measures including interest in joining a clinical trial, concerns relating to participation, and whether the respondent had previously been asked to participate. Multiple and logistic regression were used to assess the relationship between predictor and outcome variables RESULTS: Here we show the results of outcome measures regressed on main predictors related to socioeconomic status and related demographic predictors. Education, employment status, insurance coverage, and English proficiency were significant predictors of interest in clinical trial participation. Education and the presence of a healthcare professional or former clinical trial participant in the respondent's personal network were significant predictors of whether the respondent had previously been asked to participate in a clinical trial CONCLUSIONS: The results of the analysis reveal how socioeconomically vulnerable groups, including those from low income and low education groups, are being excluded in clinical research. Analyses also uncovered the impact of clinical trial social influence-the presence of having a family or friend in one's social network who participated in a clinical trial-on willingness to participate and exposure to clinical trials.
了解教育和收入方面的社会经济差异等健康的社会决定因素如何影响人们对临床试验的认知和参与情况，对于刻画社会经济弱势群体对临床试验的认知至关重要。方法：2023年春季，在一个按人口统计学变量分层的调查样本中进行了一项调查，以反映美国人口情况。调查评估了受访者的社会经济状况及相关协变量，以及包括参与临床试验的兴趣、参与相关的担忧，以及受访者此前是否曾被邀请参与等结果指标。使用多元回归和逻辑回归来评估预测变量和结果变量之间的关系。结果：在此，我们展示了以与社会经济状况相关的主要预测因素及相关人口统计学预测因素为自变量的结果指标回归分析结果。教育程度、就业状况、保险覆盖范围和英语水平是参与临床试验兴趣的显著预测因素。教育程度以及受访者个人社交网络中是否有医疗保健专业人员或曾参与临床试验的人员是受访者此前是否曾被邀请参与临床试验的显著预测因素。结论：分析结果揭示了社会经济弱势群体，包括低收入和低教育水平群体，在临床研究中是如何被排除在外的。分析还揭示了临床试验社会影响——社交网络中有参与临床试验的家人或朋友——对参与意愿和接触临床试验的影响。
