Hammeke T A, Grogan J P, Haughton V M, Pfeiffer M M, Harrington G J, Sudilovsky A
AJNR Am J Neuroradiol. 1985 May-Jun;6(3):343-8.
Clinical tolerance to the myelographic contrast media metrizamide and iopamidol was evaluated in 26 and 30 patients, respectively, with a battery of neuropsychologic tests before and after myelography in a randomized, double-blind prospective study. Twenty hospitalized patients with chronic back pain were also studied before and after computed tomography to serve as controls relative to the groups administered contrast agents. Measures of conceptual reasoning and affect were sensitive tests of adverse reactions. These paralleled the incidence of somatic reactions and correlated with the dose of contrast medium. Methodologic problems included varying intervals between myelography and psychometric evaluation among subjects and use of a less-than-ideal control group. Neuropsychologic tests appear to be sensitive for detection of subtle adverse reactions and possibly predictive of their occurrence. Iopamidol was tolerated better than metrizamide, with somatic side effects occurring in 38% of patients receiving metrizamide and in 17% of patients receiving iopamidol.
在一项随机、双盲前瞻性研究中，分别对26例和30例患者进行了脊髓造影术，在脊髓造影前后通过一系列神经心理学测试评估了对脊髓造影剂甲泛葡胺和碘帕醇的临床耐受性。还对20例患有慢性背痛的住院患者在计算机断层扫描前后进行了研究，以作为使用造影剂组的对照。概念推理和情感测量是不良反应的敏感测试。这些与躯体反应的发生率平行，并与造影剂剂量相关。方法学问题包括受试者脊髓造影和心理测量评估之间的间隔不同，以及使用了不太理想的对照组。神经心理学测试似乎对检测细微的不良反应很敏感，并且可能预测其发生。碘帕醇的耐受性优于甲泛葡胺，接受甲泛葡胺的患者中有38%出现躯体副作用，接受碘帕醇的患者中有17%出现躯体副作用。
