Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Br J Haematol. 2024 Nov;205(5):1670-1671. doi: 10.1111/bjh.19747. Epub 2024 Sep 5.
Paediatric leukaemia has a long tail of driver mutations each of which must be 'backtracked' to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases. Commentary on: Bardini et al. Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2024; 205:1883-1888.
儿科白血病有一系列长的驱动突变，每一个都必须“回溯”到出生时采集的样本，以确定亚型的产前起源。目前，Bardini 等人描述了首例成功回溯 NUTM1 重排，这揭示了这种特殊改变的生物学特征。继续回溯 NUTM1 重排以及所有白血病典型的体细胞改变，对于全面了解这些疾病的产前起源是必要的。述评：Bardini 等人。婴儿 B 细胞前体急性淋巴细胞白血病中 NUTM1 基因重排的产前起源。英国血液学杂志 2024；205：1883-1888。
