Burke J S, Warnke R A, Connors J M, Beckstead J H
Am J Clin Pathol. 1985 Jun;83(6):753-9. doi: 10.1093/ajcp/83.6.753.
A lymph node biopsy performed on a 55-year-old woman with asymptomatic generalized lymphadenopathy revealed a diffuse, malignant lymphoma composed of small to intermediate-sized lymphocytes with cerebriform-shaped nuclei; electron microscopy confirmed the nuclear complexity. The cerebriform nuclear configuration, coupled with an interfollicular pattern of nodal involvement with encroachment upon residual germinal centers, was presumptive of either mycosis fungoides or a peripheral T-cell lymphoma. Immunologic evaluation, however, indicated that the cerebriform lymphocytes represented a monoclonal B-cell population (IgM-IgD, lambda). Staining with monoclonal antibodies disclosed a phenotype of Ia+, B1+, BA-1+, BA-2+, Leu-1+; the neoplastic cells were unreactive with T-cell, lineage-specific antibodies (anti-Leu-2a, -3a, -4, -5) and with J5 (CALLA). In light of the immunophenotype and the distributional pattern, the cerebriform-shaped lymphocytes may represent an extreme morphologic variant of intermediate lymphocytic lymphoma.
对一名55岁无症状全身性淋巴结病女性进行的淋巴结活检显示，有一种弥漫性恶性淋巴瘤，由小至中等大小的淋巴细胞组成，细胞核呈脑回状；电子显微镜证实了核的复杂性。脑回状核形态，加上淋巴结受累的滤泡间模式并侵犯残留生发中心，提示为蕈样肉芽肿或外周T细胞淋巴瘤。然而，免疫评估表明，脑回状淋巴细胞代表单克隆B细胞群体（IgM-IgD，λ）。用单克隆抗体染色显示出Ia+、B1+、BA-1+、BA-2+、Leu-1+的表型；肿瘤细胞与T细胞系特异性抗体（抗Leu-2a、-3a、-4、-5）和J5（CALLA）无反应。根据免疫表型和分布模式，脑回状淋巴细胞可能代表中等淋巴细胞淋巴瘤的一种极端形态学变异。
