Shaanxi Academy of Traditional Chinese Medicine, Xi'an, China.
Food Funct. 2024 Sep 30;15(19):9598-9631. doi: 10.1039/d4fo02688h.
Plants from Moraceae are globally popular as they represent a valuable resource with wide applications in food, health-care products, and other fields. Prenylated flavonoids are important active components in Moraceae. These compounds share a flavonoid skeleton with prenylated side chain, mostly in the form of single or multiple isoprenyl substituents and benzodimethylfuran structures. So far, nearly 400 prenylated flavonoids have been found in Moraceae, especially a large number of Diels-Alder adducts, which are characteristic components of this family. Due to their distinctive structures, diverse pharmacological properties and interesting synthesis processes, these compounds have attracted considerable attention from scientists. Herein, we review the advances in the structural characteristics, bioactivities, structure-activity relationships, biosynthesis strategies and metabolism of prenylated flavonoids in Moraceae plants, aiming at strengthening research efforts and utilization toward the great untapped potential of these unique constituents in human health.
桑科植物在全球范围内广受欢迎，因为它们是一种具有广泛应用价值的资源，可应用于食品、保健品和其他领域。类黄酮是桑科植物中的重要活性成分。这些化合物具有类黄酮骨架和异戊烯侧链，主要以单或多个异戊烯取代基和苯并二甲基呋喃结构的形式存在。迄今为止，在桑科植物中已经发现了近 400 种类黄酮，特别是大量的狄尔斯-阿尔德加合物，这是该家族的特征成分。由于其独特的结构、多样化的药理活性和有趣的合成过程，这些化合物引起了科学家们的极大关注。本文综述了桑科植物中类黄酮的结构特征、生物活性、构效关系、生物合成策略和代谢方面的研究进展，旨在加强对这些独特成分在人类健康中巨大潜力的研究和利用。
