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深入了解 CD1 脂质组。

Insights into the CD1 lipidome.

机构信息

Immunocore Ltd, Experimental Immunology, Abingdon, United Kingdom.

Department of Immunology, University of Debrecen, Debrecen, Hungary.

出版信息

Front Immunol. 2024 Aug 22;15:1462209. doi: 10.3389/fimmu.2024.1462209. eCollection 2024.

DOI:10.3389/fimmu.2024.1462209
PMID:39238636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11375338/
Abstract

CD1 isoforms are MHC class I-like molecules that present lipid-antigens to T cells and have been associated with a variety of immune responses. The lipid repertoire bound and presented by the four CD1 isoforms may be influenced by factors such as the cellular lipidome, subcellular microenvironment, and the properties of the binding pocket. In this study, by shotgun mass spectrometry, we performed a comprehensive lipidomic analysis of soluble CD1 molecules. We identified 1040 lipids, of which 293 were present in all isoforms. Comparative analysis revealed that the isoforms bind almost any cellular lipid.CD1a and CD1c closely mirrored the cellular lipidome, while CD1b and CD1d showed a preference for sphingolipids. Each CD1 isoform was found to have unique lipid species, suggesting some distinct roles in lipid presentation and immune responses. These findings contribute to our understanding of the role of CD1 system in immunity and could have implications for the development of lipid-based therapeutics.

摘要

CD1 同工型是 MHC Ⅰ类样分子，可将脂质抗原呈递给 T 细胞，并与多种免疫反应相关。四种 CD1 同工型结合和呈递的脂质组可能受到细胞脂质组、亚细胞微环境和结合口袋特性等因素的影响。在这项研究中，我们通过鸟枪法质谱对可溶性 CD1 分子进行了全面的脂质组学分析。我们鉴定出 1040 种脂质，其中 293 种存在于所有同工型中。比较分析表明，同工型几乎可以结合任何细胞脂质。CD1a 和 CD1c 与细胞脂质组非常相似，而 CD1b 和 CD1d 则偏爱鞘脂。每种 CD1 同工型都发现了独特的脂质种类，提示其在脂质呈递和免疫反应中具有一些独特的作用。这些发现有助于我们了解 CD1 系统在免疫中的作用，并可能对基于脂质的治疗药物的开发产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/06803ead0182/fimmu-15-1462209-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/26ffe2fcbe72/fimmu-15-1462209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/db9804f3f383/fimmu-15-1462209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/f075d2272a11/fimmu-15-1462209-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/02a4f39b8789/fimmu-15-1462209-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/d4e6f8c6e0b1/fimmu-15-1462209-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/5be6a52ca272/fimmu-15-1462209-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/f9cd2fd9b4d3/fimmu-15-1462209-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/06803ead0182/fimmu-15-1462209-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/26ffe2fcbe72/fimmu-15-1462209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/db9804f3f383/fimmu-15-1462209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/f075d2272a11/fimmu-15-1462209-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/02a4f39b8789/fimmu-15-1462209-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/d4e6f8c6e0b1/fimmu-15-1462209-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/5be6a52ca272/fimmu-15-1462209-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/f9cd2fd9b4d3/fimmu-15-1462209-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e97/11375338/06803ead0182/fimmu-15-1462209-g008.jpg

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