Ye John H, Chen Yi-Ling, Ogg Graham
MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Clin Exp Dermatol. 2024 Apr 23;49(5):450-458. doi: 10.1093/ced/llad460.
The CD1 and MR1 protein families present lipid antigens and small molecules to T cells, complementing well-studied major histocompatibility complex-peptide mechanisms. The CD1a subtype is highly and continuously expressed within the skin, most notably on Langerhans cells, and has been demonstrated to present self and foreign lipids to T cells, highlighting its cutaneous sentinel role. Alteration of CD1a-dependent T-cell responses has recently been discovered to contribute to the pathogenesis of several inflammatory skin diseases. In this review, we overview the structure and role of CD1a and outline the current evidence implicating CD1a in the development of psoriasis, atopic dermatitis and allergic contact dermatitis.
CD1和MR1蛋白家族将脂质抗原和小分子呈递给T细胞，对已得到充分研究的主要组织相容性复合体-肽机制起到补充作用。CD1a亚型在皮肤内持续高表达，最显著的是在朗格汉斯细胞上，并且已被证明可将自身和外来脂质呈递给T细胞，凸显了其皮肤哨兵作用。最近发现，依赖CD1a的T细胞反应改变会导致几种炎症性皮肤病的发病机制。在本综述中，我们概述了CD1a的结构和作用，并概述了目前将CD1a与银屑病、特应性皮炎和过敏性接触性皮炎的发生发展联系起来的证据。
