Keklik Karadağ Fatma, Gunes Ajda, Mete Gokmen Nihal, Şahin Fahri, Saydam Guray
Department of Hematology, Izmir City Hospital, Izmir, TUR.
Department of Internal Medicine, Division of Hematology, Ege University Faculty of Medicine, Izmir, TUR.
Cureus. 2024 Aug 6;16(8):e66310. doi: 10.7759/cureus.66310. eCollection 2024 Aug.
Cyclic thrombocytopenia (CTP) is a very rare condition that is characterized by episodic thrombocytopenia over a period of three to five weeks. The pathogenesis of CTP is unclear and most likely heterogeneous; however, usually there is no clue about the underlying disease. In this case report, we presented a 48-year-old female who had a low platelet count of 66 x 10/µL (range: 150-450 x 10/µL) on her routine examination with no evidence of bleeding. On further review of her laboratory workup in the past several years, she was noted to have multiple episodes of low platelet counts. She was diagnosed with CTP after a recurrent pattern of fluctuations in her platelet count, with improvements sometimes without intervention. Unfortunately, most CTP patients are misdiagnosed as having primary immune thrombocytopenia (ITP), and CTP typically responds poorly to ITP therapy. This case underscores the need for further research and serves as a valuable reference to increase the awareness of clinicians about CTP.
周期性血小板减少症（CTP）是一种非常罕见的病症，其特征是在三到五周的时间内出现间歇性血小板减少。CTP的发病机制尚不清楚，很可能具有异质性；然而，通常没有关于潜在疾病的线索。在本病例报告中，我们介绍了一名48岁女性，她在常规检查时血小板计数低至66×10⁹/µL（范围：150 - 450×10⁹/µL），且无出血迹象。在进一步回顾她过去几年的实验室检查结果时，发现她有多次血小板计数偏低的情况。在她的血小板计数呈现反复波动模式且有时未经干预就有所改善后，她被诊断为CTP。不幸的是，大多数CTP患者被误诊为原发性免疫性血小板减少症（ITP），而且CTP对ITP治疗通常反应不佳。本病例强调了进一步研究的必要性，并为提高临床医生对CTP的认识提供了有价值的参考。
