Priya Keerthi, Deepak Kishore K, Kochhar Kanwal P, Anil Abhijith, Chandran Dinu S, Sharma Shweta, Jangra Sunil, Netam Ritesh
Department of Physiology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cureus. 2024 Aug 6;16(8):e66266. doi: 10.7759/cureus.66266. eCollection 2024 Aug.
Microgravity, as experienced during spaceflight has notable effects on the cognition and cardiovascular systems. However, its effect on motor signal processing is not known. In this study, we planned to study the effect of microgravity simulation with a lower body positive pressure of 50 mmHg on motor signal processing, reaction times, and cardiovascular parameters. Thirty healthy human volunteers participated in this investigation, and continuous ECG and non-invasive blood pressure were measured at baseline, during, and after a lower body positive pressure of 50 mmHg. Bereitschafts potential was recorded at 0 mmHg and 50 mmHg pressure values in a lower body positive pressure (LBPP) suit. Parameters recorded during the pressure change of 0 mmHg to 50 mmHg were RR interval, heart rate, systolic blood pressure, diastolic blood pressure, stroke volume, cardiac output, and peripheral vascular resistance. Heart rate variability (HRV) was calculated from RR intervals during resting and pressure of 50 mm of Hg. We also compared simple and choice reaction times for visual and auditory stimuli during 50 mmHg LBPP exposure with baseline recording. We found a significant increase in systolic blood pressure, stroke volume, and cardiac output from baseline at 50 mmHg of LBPP. We found a significant change in amplitude and area of Bereitschaft potential at the C4 site at 50 mmHg of LBPP. We found a significant change in low-frequency power (LF) as compared to the baseline in HRV. Simple reaction time (visual & auditory) and auditory choice reaction time were improved at 50 mmHg of LBPP. Motor signal processing and reaction time were improved during 50 mmHg of lower body positive pressure exposure.
太空飞行期间所经历的微重力对认知和心血管系统有显著影响。然而，其对运动信号处理的影响尚不清楚。在本研究中，我们计划研究50 mmHg下体正压模拟微重力对运动信号处理、反应时间和心血管参数的影响。30名健康人类志愿者参与了这项研究，在基线、50 mmHg下体正压期间和之后测量了连续心电图和无创血压。在下体正压（LBPP）套装中，在0 mmHg和50 mmHg压力值下记录预备电位。在压力从0 mmHg变化到50 mmHg期间记录的参数有RR间期、心率、收缩压、舒张压、每搏输出量、心输出量和外周血管阻力。根据静息和50 mmHg汞柱压力期间的RR间期计算心率变异性（HRV）。我们还将50 mmHg LBPP暴露期间视觉和听觉刺激的简单反应时间和选择反应时间与基线记录进行了比较。我们发现，在50 mmHg LBPP时，收缩压、每搏输出量和心输出量较基线显著增加。我们发现，在50 mmHg LBPP时，C4部位预备电位的幅度和面积有显著变化。我们发现，与基线相比，HRV中的低频功率（LF）有显著变化。在50 mmHg LBPP时，简单反应时间（视觉和听觉）和听觉选择反应时间有所改善。在下体正压50 mmHg暴露期间，运动信号处理和反应时间得到改善。
