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本文引用的文献

1
Clinical Features and Outcomes of Myxedema Coma in Patients Hospitalized for Hypothyroidism: Analysis of the United States National Inpatient Sample.住院甲状腺功能减退症患者黏液水肿性昏迷的临床特征和转归:美国国家住院患者样本分析。
Thyroid. 2024 Apr;34(4):419-428. doi: 10.1089/thy.2023.0559. Epub 2024 Feb 28.
2
Idiopathic Intracranial Hypertension following Levothyroxine Replacement Therapy: Systematic Review and a Case Report.左甲状腺素替代治疗后特发性颅内高压:系统评价与病例报告
Indian J Endocrinol Metab. 2023 Jan-Feb;27(1):17-24. doi: 10.4103/ijem.ijem_439_22. Epub 2023 Mar 3.
3
Pediatric Myxedema Due to Autoimmune Hypothyroidism: A Rare Complication of a Common Disorder.自身免疫性甲状腺功能减退所致小儿黏液性水肿:一种常见疾病的罕见并发症。
Children (Basel). 2023 Mar 24;10(4):614. doi: 10.3390/children10040614.
4
Publisher Correction: Hypothyroidism.出版商更正:甲状腺功能减退症。
Nat Rev Dis Primers. 2022 Jun 10;8(1):39. doi: 10.1038/s41572-022-00373-7.
5
The Myxedema coma in children and adolescents: A rare endocrine emergency - Personal experience and review of literature.儿童和青少年黏液水肿性昏迷:一种罕见的内分泌急症——个人经验和文献复习。
Acta Biomed. 2021 Nov 3;92(5):e2021481. doi: 10.23750/abm.v92i5.12252.
6
Oral Levothyroxine is an Effective Option for Myxedema Coma: A Single-Centre Experience.口服左甲状腺素是黏液性水肿昏迷的有效治疗选择:一项单中心经验。
Eur Thyroid J. 2021 Mar;10(1):52-58. doi: 10.1159/000507855. Epub 2020 Jun 11.
7
Long-Term Follow-Up and Outcomes of Autoimmune Thyroiditis in Childhood.儿童自身免疫性甲状腺炎的长期随访和结局。
Front Endocrinol (Lausanne). 2020 Jun 5;11:309. doi: 10.3389/fendo.2020.00309. eCollection 2020.
8
Thyroid emergencies.甲状腺急症。
Pol Arch Intern Med. 2019 Aug 29;129(7-8):526-534. doi: 10.20452/pamw.14876. Epub 2019 Jun 25.
9
Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine.成功应用左甲状腺素和三碘甲状腺原氨酸联合治疗黏液水肿性昏迷。
Endocr J. 2019 May 28;66(5):469-474. doi: 10.1507/endocrj.EJ18-0469. Epub 2019 Mar 8.
10
Myxedema coma: A case report of pediatric emergency care.黏液水肿性昏迷:一例儿科急诊护理病例报告。
Medicine (Baltimore). 2017 May;96(21):e6952. doi: 10.1097/MD.0000000000006952.

当预期变为意外:甲状腺功能减退症的急性表现

When the Expected Becomes Unexpected: An Acute Presentation of Hypothyroidism.

作者信息

Martinez Sanchez Andrea, Vega Castellvi Claudia, Tarkoff Joshua, De La Vega Christie

机构信息

Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL 33155, USA.

出版信息

JCEM Case Rep. 2024 Sep 5;2(9):luae154. doi: 10.1210/jcemcr/luae154. eCollection 2024 Sep.

DOI:10.1210/jcemcr/luae154
PMID:39238942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11375574/
Abstract

Myxedema coma is an uncommon and life-threatening manifestation of severe hypothyroidism. Its occurrence in the pediatric population is exceptionally rare and can result from long-standing untreated hypothyroidism or nonadherence to treatment. Identifying this condition can be challenging because it requires a high level of clinical suspicion along with thyroid function testing. We present a 17-year-old female with a history of anxiety who had widespread nonspecific symptoms, including persistent bradycardia, which were found to be caused by hypothyroidism. Our goal is to raise awareness of the varied clinical manifestations of pediatric myxedema to promote early recognition and prompt medical interventions that can lead to better outcomes.

摘要

黏液性水肿昏迷是严重甲状腺功能减退症的一种罕见且危及生命的表现。它在儿科人群中极为罕见,可能由长期未治疗的甲状腺功能减退症或不坚持治疗引起。识别这种情况具有挑战性,因为它需要高度的临床怀疑以及甲状腺功能测试。我们报告了一名17岁有焦虑病史的女性,她有广泛的非特异性症状,包括持续性心动过缓,后来发现是由甲状腺功能减退症引起的。我们的目标是提高对儿科黏液性水肿各种临床表现的认识,以促进早期识别和及时的医疗干预,从而带来更好的结果。