Pandey Archana
Kathmandu University School of Medical Sciences, Dhulikhel Hospital, Dhulikhel, Nepal.
Ann Med Surg (Lond). 2024 Jul 1;86(9):5304-5313. doi: 10.1097/MS9.0000000000002345. eCollection 2024 Sep.
Hidradenitis suppurativa, or acne inversa, is a chronic inflammatory skin condition with recurrent inflammatory nodules, abscesses, subcutaneous tracts, and scars. This condition may cause severe psychological distress and reduce the quality of life for affected individuals. It is considered to have one of the most damaging effects on quality of life of any skin disorder as a result of the discomfort and foul-smelling discharge from these lesions. Although the pathophysiology of HS is still unclear, multiple factors, including lifestyle, genetic, and hormonal factors, have been associated with it. The pathogenesis of HS is very complex and has wide clinical manifestations; thus, it is quite challenging to manage and often requires the use of combination treatments that must be tailored according to disease severity and other patient-specific factors. Although lifestyle changes, weight loss, quitting smoking, topical treatments, and oral antibiotics are adequate for mild cases, the challenge for healthcare professionals is dealing with moderate-to-severe HS, which often does not respond well to traditional approaches. This literature review, consisting of an overview of the various assessment tools and therapy strategies available for the diagnosis and treatment of HS from published literature, aims to be a guide for practicing clinicians in dealing with the complexities associated with this disease.
化脓性汗腺炎，又称反向性痤疮，是一种慢性炎症性皮肤病，表现为反复发作的炎性结节、脓肿、皮下条索和瘢痕。这种疾病可能会导致严重的心理困扰，并降低患者的生活质量。由于这些皮损会带来不适和恶臭分泌物，它被认为是对生活质量影响最大的皮肤疾病之一。尽管化脓性汗腺炎的病理生理学仍不清楚，但包括生活方式、遗传和激素因素在内的多种因素都与之相关。化脓性汗腺炎的发病机制非常复杂，临床表现多样；因此，其治疗颇具挑战性，通常需要根据疾病严重程度和其他患者特定因素采用联合治疗方案。虽然生活方式改变、体重减轻、戒烟、局部治疗和口服抗生素对轻度病例有效，但医疗专业人员面临的挑战是应对中重度化脓性汗腺炎，这类疾病往往对传统治疗方法反应不佳。这篇文献综述对已发表文献中可用于化脓性汗腺炎诊断和治疗的各种评估工具及治疗策略进行了概述，旨在为执业临床医生应对与该疾病相关的复杂性提供指导。
