混合现实支持的近红外光免疫疗法治疗口咽癌：一例报告
Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report.
作者信息
Okada Ryuhei, Ito Taku, Kawabe Hiroaki, Tsutsumi Takeshi, Asakage Takahiro
机构信息
Department of Head and Neck Surgery, Tokyo Medical and Dental University.
Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Ann Med Surg (Lond). 2024 Aug 7;86(9):5551-5556. doi: 10.1097/MS9.0000000000002366. eCollection 2024 Sep.
INTRODUCTION AND IMPORTANCE
Near-infrared photoimmunotherapy (NIR-PIT, Alluminox) uses an antibody-photoabsorber conjugate and light excitation, requiring precise illumination. Mixed reality (MR) technology can enhance medical procedures through advanced visualization and planning.
CASE PRESENTATION
An 86-year-old man with recurrent oropharyngeal cancer and right cervical metastasis received NIR-PIT. Three-dimensional models from computed tomography (CT) and FDG-PET/CT images were used as holograms on a head-mounted display (HMD) for precise light targeting.
CLINICAL DISCUSSION
HMD-MR technology was utilized for preoperative simulation and guided ideal light direction during surgery. This improved the effectiveness of NIR-PIT.
CONCLUSION
Three months post-treatment, no residual lesion was observed, demonstrating the utility of HMD-MR technology in optimizing NIR-PIT outcomes.
引言与重要性
近红外光免疫疗法（NIR-PIT，Alluminox）使用抗体-光吸收剂共轭物和光激发，需要精确照明。混合现实（MR）技术可通过先进的可视化和规划增强医疗程序。
病例介绍
一名86岁复发性口咽癌伴右颈转移的男性接受了NIR-PIT治疗。来自计算机断层扫描（CT）和FDG-PET/CT图像的三维模型被用作头戴式显示器（HMD）上的全息图，以实现精确的光靶向。
临床讨论
HMD-MR技术用于术前模拟并在手术期间引导理想的光方向。这提高了NIR-PIT的有效性。
结论
治疗后三个月，未观察到残留病变，证明了HMD-MR技术在优化NIR-PIT治疗效果方面的实用性。
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