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混合现实支持的近红外光免疫疗法治疗口咽癌：一例报告

Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report.

作者信息

Okada Ryuhei, Ito Taku, Kawabe Hiroaki, Tsutsumi Takeshi, Asakage Takahiro

机构信息

Department of Head and Neck Surgery, Tokyo Medical and Dental University.

Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.

出版信息

Ann Med Surg (Lond). 2024 Aug 7;86(9):5551-5556. doi: 10.1097/MS9.0000000000002366. eCollection 2024 Sep.

DOI:10.1097/MS9.0000000000002366
PMID:39239041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11374202/
Abstract

INTRODUCTION AND IMPORTANCE: Near-infrared photoimmunotherapy (NIR-PIT, Alluminox) uses an antibody-photoabsorber conjugate and light excitation, requiring precise illumination. Mixed reality (MR) technology can enhance medical procedures through advanced visualization and planning. CASE PRESENTATION: An 86-year-old man with recurrent oropharyngeal cancer and right cervical metastasis received NIR-PIT. Three-dimensional models from computed tomography (CT) and FDG-PET/CT images were used as holograms on a head-mounted display (HMD) for precise light targeting. CLINICAL DISCUSSION: HMD-MR technology was utilized for preoperative simulation and guided ideal light direction during surgery. This improved the effectiveness of NIR-PIT. CONCLUSION: Three months post-treatment, no residual lesion was observed, demonstrating the utility of HMD-MR technology in optimizing NIR-PIT outcomes.

摘要

引言与重要性：近红外光免疫疗法（NIR-PIT，Alluminox）使用抗体-光吸收剂共轭物和光激发，需要精确照明。混合现实（MR）技术可通过先进的可视化和规划增强医疗程序。 病例介绍：一名86岁复发性口咽癌伴右颈转移的男性接受了NIR-PIT治疗。来自计算机断层扫描（CT）和FDG-PET/CT图像的三维模型被用作头戴式显示器（HMD）上的全息图，以实现精确的光靶向。 临床讨论：HMD-MR技术用于术前模拟并在手术期间引导理想的光方向。这提高了NIR-PIT的有效性。 结论：治疗后三个月，未观察到残留病变，证明了HMD-MR技术在优化NIR-PIT治疗效果方面的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/d7e063e0948e/ms9-86-5551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/455a6cd7020e/ms9-86-5551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/ac0ff9bf1714/ms9-86-5551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/1efa7a529586/ms9-86-5551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/d7e063e0948e/ms9-86-5551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/455a6cd7020e/ms9-86-5551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/ac0ff9bf1714/ms9-86-5551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/1efa7a529586/ms9-86-5551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5f/11374202/d7e063e0948e/ms9-86-5551-g004.jpg

相似文献

[1]
Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report.

Ann Med Surg (Lond). 2024-8-7

[2]
Near-Infrared Photoimmunotherapy for Oropharyngeal Cancer.

Cancers (Basel). 2022-11-17

[3]
The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy.

Jpn J Radiol. 2024-8

[4]
Selective Photokilling of Colorectal Tumors by Near-Infrared Photoimmunotherapy with a GPA33-Targeted Single-Chain Antibody Variable Fragment Conjugate.

Mol Pharm. 2020-7-6

[5]
Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor (EGFR) antibody.

Oncotarget. 2018-4-10

[6]
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine. 2021-5

[7]
Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer.

Bioconjug Chem. 2017-5-17

[8]
Antibody Drug Conjugates of Near-Infrared Photoimmunotherapy (NIR-PIT) in Breast Cancers.

Technol Cancer Res Treat. 2023

[9]
Endoscopic near-infrared photoimmunotherapy in an orthotopic head and neck cancer model.

Cancer Sci. 2021-8

[10]
Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody.

Mol Cancer Res. 2017-6-6

引用本文的文献

[1]
Real-World Effectiveness and Safety of Photoimmunotherapy for Head and Neck Cancer: A Multicenter Retrospective Study.

Cancers (Basel). 2025-8-16

[2]
Next-Generation Cancer Treatment: Photoimmunotherapy's Promise for Unresectable Head and Neck Cancers.

Pharmaceutics. 2025-5-29

本文引用的文献

[1]
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.

Int J Surg. 2023-5-1

[2]
Utilization of ultrasound in photoimmunotherapy for head and neck cancer: a case report.

J Ultrasound. 2025-3

[3]
Photoimmunotherapy with surgical navigation and computed tomography guidance for recurrent maxillary sinus carcinoma.

Auris Nasus Larynx. 2023-8

[4]
A Case Treated With Photoimmunotherapy Under a Navigation System for Recurrent Lesions of the Lateral Pterygoid Muscle.

In Vivo. 2022

[5]
Application of a virtual and mixed reality-navigation system using commercially available devices to the lateral temporal bone resection.

Ann Med Surg (Lond). 2021-11-16

[6]
Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma.

Head Neck. 2021-12

[7]
A phase I, single-center, open-label study of RM-1929 photoimmunotherapy in Japanese patients with recurrent head and neck squamous cell carcinoma.

Int J Clin Oncol. 2021-10

[8]
Patient-specific virtual and mixed reality for immersive, experiential anatomy education and for surgical planning in temporal bone surgery.

Auris Nasus Larynx. 2021-12

[9]
Diagnostic imaging in near-infrared photoimmunotherapy using a commercially available camera for indocyanine green.

Cancer Sci. 2021-3

[10]
Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green.

Mol Pharm. 2021-3-1

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