Nishikawa Daisuke, Suzuki Hidenori, Beppu Shintaro, Terada Hoshino, Sawabe Michi, Hanai Nobuhiro
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
Cancers (Basel). 2022 Nov 17;14(22):5662. doi: 10.3390/cancers14225662.
Human papillomavirus (HPV)-associated oropharyngeal cancer has a better prognosis than other head and neck cancers. However, rates of recurrence and metastasis are similar and the prognosis of recurrent or metastatic HPV-associated oropharyngeal cancer is poor. Near-infrared photoimmunotherapy (NIR-PIT) is a treatment involving administration of a photosensitizer (IRDye700DX) conjugated to a monoclonal antibody followed by activation with near-infrared light illumination. It is a highly tumor-specific therapy with minimal toxicity in normal tissues. Moreover, NIR-PIT is expected to have not only direct effects on a treated lesion but also immune responses on untreated distant lesions. NIR-PIT with cetuximab-IR700 (AlluminoxTM) has been in routine clinical use since January 2021 for unresectable locally advanced or locally recurrent head and neck cancer in patients that have previously undergone radiotherapy in Japan. NIR-PIT for head and neck cancer (HN-PIT) is expected to provide a curative treatment option for the locoregional recurrent or metastatic disease after radiotherapy and surgery. This article reviews the mechanism underlying the effect of NIR-PIT and recent clinical trials of NIR-PIT for head and neck cancers, treatment-specific adverse events, combination treatment with immune checkpoint inhibitors, illumination approach and posttreatment quality of life, and provides a case of series of two patients who receive NIR-PIT for oropharyngeal cancer at our institution.
人乳头瘤病毒（HPV）相关的口咽癌预后比其他头颈癌更好。然而，其复发和转移率相似，复发性或转移性HPV相关口咽癌的预后较差。近红外光免疫疗法（NIR-PIT）是一种治疗方法，包括给予与单克隆抗体偶联的光敏剂（IRDye700DX），然后用近红外光照射激活。这是一种高度肿瘤特异性的疗法，对正常组织的毒性最小。此外，预计NIR-PIT不仅对治疗的病灶有直接作用，而且对未治疗的远处病灶有免疫反应。自2021年1月起，在日本，用西妥昔单抗-IR700（AlluminoxTM）进行的NIR-PIT已常规应用于先前接受过放疗的不可切除的局部晚期或局部复发性头颈癌患者。头颈癌的NIR-PIT（HN-PIT）有望为放疗和手术后局部区域复发或转移的疾病提供一种治愈性的治疗选择。本文综述了NIR-PIT作用的潜在机制以及NIR-PIT用于头颈癌的近期临床试验、治疗特异性不良事件、与免疫检查点抑制剂的联合治疗、照射方法和治疗后生活质量，并提供了我们机构中两名接受NIR-PIT治疗口咽癌患者的系列病例。
