Alirezaei Amirhesam, Miladipour Amirhossein, Asgari Navid, Latifi Marzieh, Fazeli Seyed Amirhossein
Clinical Research and Development Center, Shahid Modarres Educational Hospital, Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2024 Jul 12;29:40. doi: 10.4103/jrms.jrms_38_24. eCollection 2024.
Sarcopenia, characterized by reduced muscle strength and mass, is commonly observed in patients with kidney disease. This study aimed to investigate the factors that influence sarcopenia in patients undergoing maintenance hemodialysis (HD patients).
A case-control study was conducted from 2022 to 2023, involving a total of 137 HD patients receiving regular dialysis. Relevant data were collected, and based on diagnostic criteria, patients were classified into sarcopenia and nonsarcopenia groups. All patients received polysulfone membrane HD at a flow rate of 500 mL/min. Bioelectrical impedance analysis was used to evaluate phase angle (PhA), muscle volume, and body composition.
The prevalence of sarcopenia among maintenance HD patients was found to be 40.14%. There was a higher proportion of women (76.36%) with sarcopenia compared to men ( < 0.001). Furthermore, a significant difference was observed in PhA ( < 0.006) between patients undergoing maintenance HD with and without sarcopenia. PhA was positively associated with body mass index, body cell mass, basal metabolic rate, fat-free mass, soft lean mass, and minerals, whereas age and skeletal muscle index showed an inverse significant correlation.
Sarcopenia, a condition associated with increased mortality risk, affects a considerable proportion of dialysis patients. It is imperative to urgently identify and develop preventive and therapeutic strategies to counteract the detrimental effects of sarcopenia on the health outcomes of kidney patients.
肌肉减少症以肌肉力量和质量下降为特征，常见于肾病患者。本研究旨在调查维持性血液透析患者（HD患者）中影响肌肉减少症的因素。
2022年至2023年进行了一项病例对照研究，共纳入137例接受规律透析的HD患者。收集相关数据，并根据诊断标准将患者分为肌肉减少症组和非肌肉减少症组。所有患者均采用聚砜膜以500 mL/min的血流量进行血液透析。采用生物电阻抗分析评估相位角（PhA）、肌肉体积和身体成分。
维持性HD患者中肌肉减少症的患病率为40.14%。肌肉减少症女性患者比例（76.36%）高于男性（<0.001）。此外，有和没有肌肉减少症的维持性HD患者之间的PhA存在显著差异（<0.006）。PhA与体重指数、身体细胞质量、基础代谢率、去脂体重、瘦软组织质量和矿物质呈正相关，而年龄和骨骼肌指数呈显著负相关。
肌肉减少症与死亡风险增加相关，影响相当比例的透析患者。迫切需要确定并制定预防和治疗策略，以对抗肌肉减少症对肾病患者健康结局的不利影响。
