分析金属诱导的遗传毒性终点。
Profiling Metal-Induced Genotoxic Endpoints.
作者信息
Shoeb Mohammad, Zarus Gregory M, Abadin Henry E
机构信息
Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention.
出版信息
J Environ Health. 2023 Dec;86(5):30-35.
Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double- and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure-induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.
许多有毒金属参与DNA损伤的起始和进展，这可能导致双链和单链DNA处的DNA损伤反应机制激活；这种反应可能导致整体和基因特异性的DNA改变。美国毒物与疾病登记署（ATSDR）的毒理学概况以及其他几项研究表明了金属暴露诱导的遗传毒性终点和表观遗传修饰的影响。我们的综述系统地总结了来自ATSDR毒理学概况和现有文献的越来越多的证据，这些证据表明各种遗传毒性终点和金属暴露之间可能存在诱导关系。我们在本文中纳入了关于铬、砷、镍、铅、汞和锌的研究。
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