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脊髓刺激可能会减轻转移性结肠癌患者的腰椎神经根病。

Spinal cord stimulation may reduce lumbar radiculopathy in the setting of metastatic colon cancer.

作者信息

Chopra Harman, Jackels Melissa, Kumar Arvind Senthil, Broachwala Mustafa, AlFarra Tariq, Castellanos Joel

机构信息

Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Division of Pain Medicine, University of California San Diego Medical Center San Diego, CA, USA.

出版信息

Interv Pain Med. 2023 Dec 15;2(4):100374. doi: 10.1016/j.inpm.2023.100374. eCollection 2023 Dec.

Abstract

Cancer pain has a substantial impact on the quality of life and functional capacity with a prevalence of up to 70 % in patients with advanced, metastatic, or terminal disease [1]. The WHO pain ladder has been used in practice to guide cancer pain management. A three-step ladder starts with NSAIDs and non-opioids for mild pain, weak opioids for mild to moderate pain and strong opioids for moderate to severe pain with the use of adjuvant medications such as TCAs and muscle relaxants at any stage for optimization (Fallon et al., Dec 2022) [2] We present a case of a patient with metastatic colon cancer who was admitted for intractable pain crisis and right sided L-5 radiculopathy secondary to epidural metastasis (Figs. 1 and 2). The patient's pain left her bedridden, unable to walk and remained refractory to an escalating intravenous opioid regimen and caudal epidural steroids. The patient subsequently underwent spinal cord stimulation (SCS) trial at level T-7 and achieved >80 % pain relief resulting in a markedly decreased opioid requirement and tremendous recovery of ambulatory function (Fig. 3). After sustained results, a permanent implant was placed at T-8 and patient remains discharged with functional restoration and continued pain improvement (Fig. 4). To our knowledge, this is a novel application of SCS for a refractory pain crisis secondary to a metastatic colon cancer induced radiculopathy presenting with severe functional impairment. As we transition away from opioid use, it is imperative as pain physicians, to investigate the potential of current as an alternative means of cancer pain management: a ubiquitous and challenging clinical conundrum.

摘要

癌症疼痛对生活质量和功能能力有重大影响,在晚期、转移性或终末期疾病患者中的患病率高达70%[1]。世界卫生组织疼痛阶梯已在实践中用于指导癌症疼痛管理。三步阶梯法始于使用非甾体抗炎药(NSAIDs)和非阿片类药物治疗轻度疼痛,弱阿片类药物治疗轻度至中度疼痛,强阿片类药物治疗中度至重度疼痛,并在任何阶段使用辅助药物,如三环类抗抑郁药(TCAs)和肌肉松弛剂以优化治疗(法伦等人,2022年12月)[2]。我们报告一例转移性结肠癌患者,因顽固性疼痛危机和硬膜外转移继发的右侧L-5神经根病入院(图1和图2)。患者的疼痛使其卧床不起,无法行走,对逐渐增加剂量的静脉注射阿片类药物方案和骶管硬膜外类固醇治疗仍无反应。该患者随后在T-7水平进行了脊髓刺激(SCS)试验,疼痛缓解超过80%,导致阿片类药物需求量显著减少,步行功能大幅恢复(图3)。在持续取得良好效果后,在T-8水平植入了永久性装置,患者出院时功能恢复,疼痛持续改善(图4)。据我们所知,这是SCS在转移性结肠癌诱发神经根病继发顽固性疼痛危机并伴有严重功能障碍中的新应用。随着我们逐渐减少阿片类药物的使用,作为疼痛科医生,必须研究当前方法作为癌症疼痛管理替代手段的潜力:这是一个普遍存在且具有挑战性的临床难题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be4/11372977/069238348426/gr1.jpg

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