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男性衰老过程中的垂体 - 性腺系统。

Hypophyseal-gonadal system during male aging.

作者信息

Moroz E V, Verkhratsky N S

出版信息

Arch Gerontol Geriatr. 1985 Apr;4(1):13-9. doi: 10.1016/0167-4943(85)90013-5.

DOI:10.1016/0167-4943(85)90013-5
PMID:3923957
Abstract

The concentration of sex and gonadotropic hormones in blood plasma of 280 reasonably healthy men aged 20-105 was determined using radioimmunoassay kits. Compared to men aged 20-39, the statistically significant decrease in testosterone level was registered in men aged 55-59, the increase in oestradiol in men aged 60-64, progesterone in men aged 55-59, and in LH and FSH in the group aged 65-69. The reactivity of central and peripheral links of the hypothalamic-gonadal system to direct and feed-back control influences alters with age.

摘要

采用放射免疫分析试剂盒测定了280名年龄在20 - 105岁之间、健康状况尚佳的男性血浆中性激素和促性腺激素的浓度。与20 - 39岁的男性相比,55 - 59岁男性的睾酮水平有统计学意义的下降,60 - 64岁男性的雌二醇水平升高,55 - 59岁男性的孕酮水平升高,65 - 69岁组的促黄体生成素(LH)和促卵泡生成素(FSH)水平升高。下丘脑 - 性腺系统的中枢和外周环节对直接和反馈控制影响的反应性随年龄而改变。

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Ann Saudi Med. 2008 May-Jun;28(3):174-8. doi: 10.5144/0256-4947.2008.174.
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Attenuated release of biologically active luteinizing hormone in healthy aging men.健康老年男性中生物活性促黄体生成素的缓释
J Clin Invest. 1988 Apr;81(4):1020-9. doi: 10.1172/JCI113412.