Bale Tracy L, Epperson C Neill
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn PROMOTES Research on Sex and Gender in Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Neuropsychopharmacology. 2017 Jan;42(2):386-396. doi: 10.1038/npp.2016.215. Epub 2016 Sep 23.
The inclusion of sex as a biological variable in research is absolutely essential for improving our understanding of disease mechanisms contributing to risk and resilience. Studies focusing on examining sex differences have demonstrated across many levels of analyses and stages of brain development and maturation that males and females can differ significantly. This review will discuss examples of animal models and clinical studies to provide guidance and reference for the inclusion of sex as an important biological variable relevant to a Neuropsychopharmacology audience.
将性别作为生物学变量纳入研究对于增进我们对导致风险和恢复力的疾病机制的理解绝对至关重要。聚焦于研究性别差异的诸多分析层面以及大脑发育和成熟阶段的研究均已表明，男性和女性可能存在显著差异。本综述将讨论动物模型和临床研究的实例，以为将性别作为与神经精神药理学领域相关的重要生物学变量纳入研究提供指导和参考。
