Liu Siqi, Guo Hui, Li Di, Wang Chunxi
Department of Urology, General Surgery Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130061, P. R. China.
Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130061, P. R. China.
J Mater Chem B. 2024 Oct 9;12(39):9821-9834. doi: 10.1039/d3tb03044j.
Prostate cancer (PCa) is one of the most common malignant neoplasms affecting the male population. The onset of the disease is insidious and often associated with severe consequences, such as bone metastases at the time of initial diagnosis. Once it advances to metastatic castration-resistant PCa (mCRPC), conventional treatment methods become ineffective. As research on the mechanism of tumor therapy advances, immunotherapy has been evolving rapidly. However, PCa is a solid tumor type that primarily faces the challenges of poor immunogenicity and inhibitory tumor microenvironment (TME). Fortunately, the extensive use of biomaterials has led to continuous advancement in PCa immunotherapy. These innovative materials aim to address intractable issues, such as immune escape and immune desert, to inhibit tumor progression and metastasis. This detailed review focuses on the regulation of different aspects of tumor immunity by immunologically effective biomaterials, including modulating adaptive immunity, innate immunity, and the immune microenvironment, to enhance the efficacy of PCa immunotherapy. In addition, this review provides a perspective on the future prospects of immunotherapeutic nanoplatforms based on biomaterials in the treatment of PCa.
前列腺癌（PCa）是影响男性人群的最常见恶性肿瘤之一。该疾病的发病隐匿，且常伴有严重后果，如在初次诊断时就发生骨转移。一旦发展为转移性去势抵抗性前列腺癌（mCRPC），传统治疗方法就会失效。随着肿瘤治疗机制研究的进展，免疫疗法发展迅速。然而，PCa是一种实体瘤类型，主要面临免疫原性差和肿瘤微环境（TME）抑制等挑战。幸运的是，生物材料的广泛应用推动了PCa免疫治疗的不断进步。这些创新材料旨在解决诸如免疫逃逸和免疫沙漠等棘手问题，以抑制肿瘤进展和转移。这篇详细综述聚焦于具有免疫效应的生物材料对肿瘤免疫不同方面的调节作用，包括调节适应性免疫、固有免疫和免疫微环境，以提高PCa免疫治疗的疗效。此外，本综述还展望了基于生物材料的免疫治疗纳米平台在PCa治疗中的未来前景。
