叔胺的环境友好型α,β-C(sp) -H双官能团化：连续的[1,5]-氢转移和杂-Diels-Alder环化反应
Eco-friendly α,β-C(sp)-H difunctionalization of tertiary amines sequential [1,5]-hydride transfer and hetero-Diels-Alder cyclization.
作者信息
Zhang Yi, Yan Huihui, Zhao Peng, Chen Rener, Fang Weiwei, Wang Lei, Ma Yongmin
机构信息
Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, 1139 Shifu Avenue Taizhou, 318000, People's Republic of China.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
出版信息
Chem Commun (Camb). 2024 Sep 24;60(77):10712-10715. doi: 10.1039/d4cc02858a.
An unprecedented eco-friendly multi-component domino reaction for the synthesis of novel ,-acetals is reported. The protocol involves sequential coupling, [1,5]-hydride transfer and hetero-Diels-Alder cyclization. This new strategy enables direct α,β-difunctionalization of cyclic amines utilizing enamines generated . The methodology features high atom and step economy, excellent regioselectivity, a simple work-up procedure and molecular diversity.
报道了一种用于合成新型α，β-缩醛的前所未有的环保多组分多米诺反应。该方案包括顺序偶联、[1,5]-氢转移和杂环狄尔斯-阿尔德环化。这种新策略能够利用生成的烯胺对环状胺进行直接α，β-双官能化。该方法具有高原子经济性和步骤经济性、优异的区域选择性、简单的后处理程序以及分子多样性。
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