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减重手术改善糖尿病性心肌病的作用:分子机制和治疗观点(综述)。

Role of bariatric surgery in improving diabetic cardiomyopathy: Molecular mechanisms and therapeutic perspectives (Review).

机构信息

Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Institute of Hepatobiliary Pancreatic Intestinal Diseases, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

出版信息

Mol Med Rep. 2024 Nov;30(5). doi: 10.3892/mmr.2024.13323. Epub 2024 Sep 6.

Abstract

Diabetic cardiomyopathy (DCM), a significant complication of diabetes mellitus, is marked by myocardial structural and functional alterations due to chronic hyperglycemia. Despite its clinical significance, optimal treatment strategies are still elusive. Bariatric surgery via sleeve gastrectomy and Roux-en-Y gastric bypass have shown promise in treating morbid obesity and associated metabolic disorders including improvements in diabetes mellitus and DCM. The present study reviews the molecular mechanisms by which bariatric surgery improves DCM, offering insights into potential therapeutic targets. Future research should further investigate the mechanistic links between bariatric surgery and DCM, to evaluate the benefits and limitations of these surgical interventions for DCM treatment. The present study aims to provide a foundation for more effective DCM therapies, contributing to the advancement of patient care.

摘要

糖尿病心肌病(DCM)是糖尿病的一种严重并发症,其特征是由于慢性高血糖导致心肌结构和功能改变。尽管其具有临床意义,但仍缺乏最佳的治疗策略。袖状胃切除术和 Roux-en-Y 胃旁路术的减重手术已显示出在治疗病态肥胖和相关代谢紊乱方面的潜力,包括改善糖尿病和 DCM。本研究综述了减重手术改善 DCM 的分子机制,为潜在的治疗靶点提供了见解。未来的研究应进一步探讨减重手术与 DCM 之间的机制联系,以评估这些手术干预措施对 DCM 治疗的益处和局限性。本研究旨在为更有效的 DCM 治疗方法提供基础,为患者护理的进步做出贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11411234/dc56e9c8d062/mmr-30-05-13323-g00.jpg

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