Division of Foregut and Bariatric Surgery, Geisinger Medical Center, Danville, Pennsylvania.
Obesity Research Institute, Geisinger Medical Center, Danville, Pennsylvania.
Surg Obes Relat Dis. 2019 May;15(5):725-731. doi: 10.1016/j.soard.2018.12.019. Epub 2018 Dec 22.
Bariatric surgery is the most effective treatment of obesity. There are few studies evaluating long-term outcomes in elderly patients.
Our study was designed to evaluate the safety and long-term outcomes of bariatric surgery in the elderly compared with a contemporary medically managed cohort.
University hospital.
Three hundred thirty-seven patients age ≥60 who underwent a sleeve gastrectomy or Roux-en-Y gastric bypass between January 2007 and April 2017 were identified (ElderSurg) and compared with a matched cohort of medically managed elderly patients with obesity (ElderNonSurg).
Thirty-two patients underwent laparoscopic sleeve gastrectomy, 190 underwent laparoscopic Roux-en-Y gastric bypass, and 115 underwent open Roux-en-Y gastric bypass. The cohort was a mean of 64.4-years old, 75.4% female, mean preoperative body mass index was 46.9, and 62.6% had type 2 diabetes. During a median follow-up period of 56.2 months (confidence interval 49.5-62.9), mean percent excess weight loss (EWL) at nadir was 72.1 ± 24.7% and EWL at 36 months or beyond was 60.9 ± 27.6%. On regression analysis, diabetes, body mass index, and laparoscopic sleeve gastrectomy were negatively associated with EWL at all time periods (P < .05). Mean %EWL was greater for Roux-en-Y gastric bypass compared with laparoscopic sleeve gastrectomy (61.7 versus 41.2; P = .039). Diabetes remission rate was 45.8%. There was a statistically significant decrease in the risk of death in ElderSurg (hazard ratio .584, 95% confidence interval .362-.941) compared with ElderNonSurg.
Our study supports that bariatric surgery is safe in elderly patients with effective long-term control of obesity, diabetes, and with improved overall survival.
减重手术是治疗肥胖症最有效的方法。目前,评估老年患者长期疗效的研究较少。
本研究旨在评估与同期接受医学管理的肥胖老年患者相比,老年患者接受减重手术的安全性和长期疗效。
大学医院。
共纳入 337 例年龄≥60 岁的患者,这些患者在 2007 年 1 月至 2017 年 4 月期间接受了袖状胃切除术或 Roux-en-Y 胃旁路术(ElderSurg),并与同期接受医学管理的肥胖老年患者(ElderNonSurg)进行了匹配。
32 例患者接受了腹腔镜袖状胃切除术,190 例患者接受了腹腔镜 Roux-en-Y 胃旁路术,115 例患者接受了开腹 Roux-en-Y 胃旁路术。该队列的平均年龄为 64.4 岁,75.4%为女性,平均术前体重指数为 46.9,62.6%合并 2 型糖尿病。在中位随访期 56.2 个月(置信区间 49.5-62.9)时,最低时的体重减轻百分比(EWL)为 72.1±24.7%,36 个月或以上时的 EWL 为 60.9±27.6%。回归分析显示,糖尿病、体重指数和腹腔镜袖状胃切除术与所有时间段的 EWL 呈负相关(P<.05)。与腹腔镜袖状胃切除术相比,Roux-en-Y 胃旁路术的平均 EWL 更高(61.7%比 41.2%;P=0.039)。糖尿病缓解率为 45.8%。与 ElderNonSurg 相比,ElderSurg 的死亡风险显著降低(风险比 0.584,95%置信区间 0.362-0.941)。
本研究支持在老年肥胖患者中实施减重手术是安全的,可有效长期控制肥胖、糖尿病,并改善总体生存率。