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年龄是肥胖症手术的实际还是感知到的歧视因素?对老年肥胖症手术的长期分析。

Is age a real or perceived discriminator for bariatric surgery? A long-term analysis of bariatric surgery in the elderly.

机构信息

Division of Foregut and Bariatric Surgery, Geisinger Medical Center, Danville, Pennsylvania.

Obesity Research Institute, Geisinger Medical Center, Danville, Pennsylvania.

出版信息

Surg Obes Relat Dis. 2019 May;15(5):725-731. doi: 10.1016/j.soard.2018.12.019. Epub 2018 Dec 22.

Abstract

BACKGROUND

Bariatric surgery is the most effective treatment of obesity. There are few studies evaluating long-term outcomes in elderly patients.

OBJECTIVES

Our study was designed to evaluate the safety and long-term outcomes of bariatric surgery in the elderly compared with a contemporary medically managed cohort.

SETTING

University hospital.

METHODS

Three hundred thirty-seven patients age ≥60 who underwent a sleeve gastrectomy or Roux-en-Y gastric bypass between January 2007 and April 2017 were identified (ElderSurg) and compared with a matched cohort of medically managed elderly patients with obesity (ElderNonSurg).

RESULTS

Thirty-two patients underwent laparoscopic sleeve gastrectomy, 190 underwent laparoscopic Roux-en-Y gastric bypass, and 115 underwent open Roux-en-Y gastric bypass. The cohort was a mean of 64.4-years old, 75.4% female, mean preoperative body mass index was 46.9, and 62.6% had type 2 diabetes. During a median follow-up period of 56.2 months (confidence interval 49.5-62.9), mean percent excess weight loss (EWL) at nadir was 72.1 ± 24.7% and EWL at 36 months or beyond was 60.9 ± 27.6%. On regression analysis, diabetes, body mass index, and laparoscopic sleeve gastrectomy were negatively associated with EWL at all time periods (P < .05). Mean %EWL was greater for Roux-en-Y gastric bypass compared with laparoscopic sleeve gastrectomy (61.7 versus 41.2; P = .039). Diabetes remission rate was 45.8%. There was a statistically significant decrease in the risk of death in ElderSurg (hazard ratio .584, 95% confidence interval .362-.941) compared with ElderNonSurg.

CONCLUSIONS

Our study supports that bariatric surgery is safe in elderly patients with effective long-term control of obesity, diabetes, and with improved overall survival.

摘要

背景

减重手术是治疗肥胖症最有效的方法。目前,评估老年患者长期疗效的研究较少。

目的

本研究旨在评估与同期接受医学管理的肥胖老年患者相比,老年患者接受减重手术的安全性和长期疗效。

设置

大学医院。

方法

共纳入 337 例年龄≥60 岁的患者,这些患者在 2007 年 1 月至 2017 年 4 月期间接受了袖状胃切除术或 Roux-en-Y 胃旁路术(ElderSurg),并与同期接受医学管理的肥胖老年患者(ElderNonSurg)进行了匹配。

结果

32 例患者接受了腹腔镜袖状胃切除术,190 例患者接受了腹腔镜 Roux-en-Y 胃旁路术,115 例患者接受了开腹 Roux-en-Y 胃旁路术。该队列的平均年龄为 64.4 岁,75.4%为女性,平均术前体重指数为 46.9,62.6%合并 2 型糖尿病。在中位随访期 56.2 个月(置信区间 49.5-62.9)时,最低时的体重减轻百分比(EWL)为 72.1±24.7%,36 个月或以上时的 EWL 为 60.9±27.6%。回归分析显示,糖尿病、体重指数和腹腔镜袖状胃切除术与所有时间段的 EWL 呈负相关(P<.05)。与腹腔镜袖状胃切除术相比,Roux-en-Y 胃旁路术的平均 EWL 更高(61.7%比 41.2%;P=0.039)。糖尿病缓解率为 45.8%。与 ElderNonSurg 相比,ElderSurg 的死亡风险显著降低(风险比 0.584,95%置信区间 0.362-0.941)。

结论

本研究支持在老年肥胖患者中实施减重手术是安全的,可有效长期控制肥胖、糖尿病,并改善总体生存率。

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