Hubers Nikki, Page Christian M, Ligthart Lannie, Pool René, Hottenga Jouke-Jan, van Dongen Jenny, Lambalk Cornelis B, Harris Jennifer R, Willemsen Gonneke, Boomsma Dorret I
Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands.
Twin Res Hum Genet. 2024 Jun;27(3):135-141. doi: 10.1017/thg.2024.26. Epub 2024 Sep 6.
Previous studies have shown that mothers of naturally conceived dizygotic (DZ) twins tend to be taller, older, and smoke more than mothers of naturally conceived monozygotic (MZ) twin and mothers of singletons. Here, we investigate whether mothers of naturally conceived DZ twins differ from mothers who conceived their DZ twins after medically assisted reproduction (MAR) in eight maternal traits related to fertility based on observational survey data. We include data from 33,648 mothers from the Netherlands Twin Register (NTR) and 1660 mothers of twins from the Norwegian Mother, Father and Child Cohort Study (MoBA). We contrast mothers of naturally conceived DZ twins with mothers of MAR DZ twins. Next, we further segment the MAR group into mothers who underwent hormonal induction of ovulation but not in vitro fertilization (IVF) and those who IVF twins, comparing them both to each other and against the mothers of naturally conceived DZ twins. Mothers of naturally conceived DZ twins smoke more often, differ in body composition, have a higher maternal age and have more offspring before the twins than mothers of MZ twins. Compared to MAR DZ twin mothers, mothers of naturally conceived DZ twins have fewer miscarriages, lower maternal age and increased height, more offspring and are more often smokers. BMI before the twin pregnancy is similar in both natural and MAR DZ twin mothers. Mothers who received hormonal induction of ovulation (OI) have a lower maternal age, fewer miscarriages, and a higher number of offspring before their twin pregnancy than twin mothers who received IVF and/or intracytoplasmic sperm injection (ICSI) treatments. Our study shows that twin mothers are a heterogenous group and the differences between twin mothers should be taken into account in epidemiological and genetic research that includes twins.
以往研究表明，自然受孕的异卵双胞胎母亲往往比自然受孕的同卵双胞胎母亲和单胎母亲更高、年龄更大、吸烟更多。在此，我们基于观察性调查数据，研究自然受孕的异卵双胞胎母亲与通过医学辅助生殖（MAR）受孕的异卵双胞胎母亲在与生育相关的八个母体特征方面是否存在差异。我们纳入了来自荷兰双胞胎登记处（NTR）的33648名母亲以及来自挪威母亲、父亲和儿童队列研究（MoBA）的1660名双胞胎母亲的数据。我们将自然受孕的异卵双胞胎母亲与医学辅助生殖受孕的异卵双胞胎母亲进行对比。接下来，我们将医学辅助生殖组进一步细分为接受激素诱导排卵但未进行体外受精（IVF）的母亲和接受体外受精双胞胎的母亲，将她们相互比较，并与自然受孕的异卵双胞胎母亲进行比较。自然受孕的异卵双胞胎母亲比同卵双胞胎母亲吸烟更频繁，身体组成不同，产妇年龄更高，在怀双胞胎之前有更多的子女。与医学辅助生殖受孕的异卵双胞胎母亲相比，自然受孕的异卵双胞胎母亲流产较少，产妇年龄较低，身高增加，子女更多，且吸烟更频繁。自然受孕和医学辅助生殖受孕的异卵双胞胎母亲在怀双胞胎前的体重指数相似。接受激素诱导排卵（OI）的母亲比接受体外受精和/或卵胞浆内单精子注射（ICSI）治疗的双胞胎母亲产妇年龄更低，流产更少，在怀双胞胎之前有更多的子女。我们的研究表明，双胞胎母亲是一个异质群体，在包括双胞胎的流行病学和基因研究中应考虑双胞胎母亲之间的差异。
