Vaziri N D, Winer R L, Alikhani S, Danviryasup K, Toohey J, Hung E, Gordon S, Eltorai I, Paule P
Arch Phys Med Rehabil. 1985 May;66(5):307-9.
Plasma antithrombin III activity and concentration were determined in nine men with end-stage renal disease (ESRD) associated with spinal cord injury (SCI). To determine the possible effects of hemodialysis measurements were repeated following dialysis. Values obtained in the SCI-ESRD group were compared with those obtained in a group of healthy volunteers and a group of 10 ambulatory men with ESRD. A normal pooled plasma was used as the internal standard for all assays. While antithrombin deficiency was observed in both uremic groups it was most severe in the group with SCI. Results demonstrated the association of antithrombin deficiency with ESRD and its potentiation in the presence of SCI. The mechanisms by which SCI compounds the uremia-induced antithrombin deficiency were not known. A mild increase in antithrombin level was noted following dialysis and was thought to be in part due to fluid removal by dialysis.
对9名患有与脊髓损伤（SCI）相关的终末期肾病（ESRD）的男性进行了血浆抗凝血酶III活性和浓度的测定。为了确定血液透析的可能影响，透析后重复进行测量。将SCI-ESRD组获得的值与一组健康志愿者以及一组10名患有ESRD的非卧床男性获得的值进行比较。使用正常混合血浆作为所有测定的内标。虽然在两个尿毒症组中均观察到抗凝血酶缺乏，但在SCI组中最为严重。结果表明抗凝血酶缺乏与ESRD相关，并且在存在SCI的情况下其情况会加重。SCI加剧尿毒症诱导的抗凝血酶缺乏的机制尚不清楚。透析后抗凝血酶水平有轻微升高，认为部分原因是透析导致的液体清除。
