Key Laboratory for Bioarcheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases, Chongqing University Three Gorges Hospital, Chongqing 404000, China.
ACS Appl Mater Interfaces. 2024 Sep 18;16(37):49660-49672. doi: 10.1021/acsami.4c11370. Epub 2024 Sep 6.
Atherosclerosis is a persistent inflammatory condition of the blood vessels associated with abnormalities in lipid metabolism. Development of biomimetic nanoplatforms provides an effective strategy. Herein, inspired by the peptide CLIKKPF spontaneously coupling to phosphatidylserine (PS) on the inner leaflet of cell membranes specifically, MM@NPs were constructed by macrophage membrane spontaneous encapsulation of cyclodextrin-based nanoparticles modified with the peptide CLIKKPF and loaded with the hydrophobic compound resveratrol. MM@NPs could be specifically phagocytized by the activated endothelium with the overexpressed VCAM-1 for enhancing target delivery into the pathological lesion. Additionally, for the ApoE mice, MM@NPs provide comprehensive treatment efficiency in reducing oxidant stress, alleviating the inherent inflammation, and decreasing cholesterol deposition, subsequently resulting in the atherosclerotic plaque regression. Therefore, MM@NPs could be one possible candidate for improving lipid metabolism and inflammation in atherosclerosis.
动脉粥样硬化是一种与脂质代谢异常相关的持续性血管炎症状态。仿生纳米平台的发展提供了一种有效的策略。在此，受肽 CLIKKPF 自发与细胞膜内层的磷脂酰丝氨酸（PS）偶联的启发，通过用肽 CLIKKPF 修饰的环糊精纳米颗粒的巨噬细胞膜自发包封构建了 MM@NPs，并负载疏水性化合物白藜芦醇。MM@NPs 可以被激活的内皮细胞特异性吞噬，内皮细胞高表达 VCAM-1 以增强向病理损伤部位的靶向递送。此外，对于 ApoE 小鼠，MM@NPs 在降低氧化应激、缓解固有炎症和减少胆固醇沉积方面提供了全面的治疗效果，从而导致动脉粥样硬化斑块消退。因此，MM@NPs 可能是改善动脉粥样硬化中脂质代谢和炎症的一种候选药物。
