Bast E J, Slaper-Cortenbach C M, Verdonck L F, Samson W, Ballieux R E
Br J Haematol. 1985 May;60(1):91-7. doi: 10.1111/j.1365-2141.1985.tb07389.x.
Two cases of transient biclonal gammopathy are described, one having an IgG kappa and an IgA kappa monoclonal component and another with IgG1 kappa and IgG4 kappa monoclonal components. In both of these cases the second monoclonal component gradually disappeared. Anti-idiotypic antibodies were made against the major monoclonal serum component; in the first case the idiotype of the IgG kappa clone was not found in the IgA kappa plasma cells (real biclonal gammopathy) whereas in the second case the idiotypes of the two clones were identical (apparent biclonal gammopathy). The evolution to monoclonal gammopathy is discussed with regard to the existence of common malignant precursor cells in biclonal gammopathy.
本文描述了两例短暂性双克隆丙种球蛋白病，一例具有IgG κ和IgA κ单克隆成分，另一例具有IgG1 κ和IgG4 κ单克隆成分。在这两例中，第二种单克隆成分逐渐消失。针对主要单克隆血清成分制备了抗独特型抗体；在第一例中，IgA κ浆细胞中未发现IgG κ克隆的独特型（真正的双克隆丙种球蛋白病），而在第二例中，两个克隆的独特型相同（表观双克隆丙种球蛋白病）。结合双克隆丙种球蛋白病中共同恶性前体细胞的存在情况，讨论了向单克隆丙种球蛋白病的演变。
