Emeis J J, Kluft C
Blood. 1985 Jul;66(1):86-91.
Platelet-activating factor (PAF-acether; 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) induced the release of plasminogen activator in rat, both in vivo and in perfused hind legs. The released plasminogen activator was shown by immunologic and functional criteria to be tissue-type plasminogen activator (t-PA). Release of t-PA by PAF-acether could be inhibited by phospholipase inhibitors and by lipoxygenase inhibitors, but not by cyclooxygenase inhibitors. It is suggested that PAF-acether induces the release of t-PA from vascular endothelial cells by the (calcium-dependent) activation of a phospholipase-lipoxygenase pathway.
血小板活化因子（PAF-乙醚；1-0-十八烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）在体内和灌注的大鼠后腿中均能诱导纤溶酶原激活物的释放。通过免疫学和功能标准表明，释放的纤溶酶原激活物为组织型纤溶酶原激活物（t-PA）。PAF-乙醚诱导的t-PA释放可被磷脂酶抑制剂和脂氧合酶抑制剂抑制，但不能被环氧化酶抑制剂抑制。提示PAF-乙醚通过（钙依赖性）激活磷脂酶-脂氧合酶途径诱导血管内皮细胞释放t-PA。
